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    Phactr3 phosphatase and actin regulator 3 [ Mus musculus (house mouse) ]

    Gene ID: 74189, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Phactr3provided by MGI
    Official Full Name
    phosphatase and actin regulator 3provided by MGI
    Primary source
    MGI:MGI:1921439
    See related
    Ensembl:ENSMUSG00000027525 AllianceGenome:MGI:1921439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H17739; Scapin1; Scapinin; mKIAA4224; 1500003N10Rik; 4930415A02Rik
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; skeletal muscle; testis; and trunk. Orthologous to human PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 15.2), cortex adult (RPKM 14.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phactr3 in Genome Data Viewer
    Location:
    2 H4; 2 99.67 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177760768..177980285)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178118975..178338492)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:177757807-177758108 Neighboring gene zinc finger protein 971 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177792959-177793260 Neighboring gene STARR-seq mESC enhancer starr_06699 Neighboring gene zinc finger protein 931 Neighboring gene synaptonemal complex protein 2 Neighboring gene GC-rich promoter binding protein 1 pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paramutation-like effects at the mouse scapinin (Phactr3) locus. Worch S, et al. J Mol Biol, 2008 Mar 28. PMID 18295233
    2. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain. Miyata T, et al. Biochem Biophys Res Commun, 2020 Jul 23. PMID 32423795
    3. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. Worch S, et al. Cytogenet Genome Res, 2006. PMID 16974080
    4. Different expression patterns of Phactr family members in normal and injured mouse brain. Kim JY, et al. Neuroscience, 2012 Sep 27. PMID 22766235
    5. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. Park CS, et al. BMC Genomics, 2013 Aug 8. PMID 23927422, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
      Title: Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
    2. This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain.
      Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
    3. Phactr3 exon 1C splice variant is potentially strain specific regulated, leading to the expression of only one allele of the reciprocal crosses.
      Title: Paramutation-like effects at the mouse scapinin (Phactr3) locus.
    4. Expression analysis in the mouse revealed a tissue-specific complex transcription pattern in the brain and a specific pattern was observed during prenatal development
      Title: Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4224

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 3
    Names
    scaffold-associated PP1-inhibiting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007154.3 → NP_001007155.1  phosphatase and actin regulator 3 isoform 2

      See identical proteins and their annotated locations for NP_001007155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK038449, AL772217, BY127674
      Consensus CDS
      CCDS17159.1
      UniProtKB/TrEMBL
      Q5DTG6, Q6KCA9
      Related
      ENSMUSP00000099354.2, ENSMUST00000103065.2
      Conserved Domains (2) summary
      smart00707
      Location:399 → 423
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:353 → 506
      DUF5401; Family of unknown function (DUF5401)

    2. NM_001177789.1 → NP_001171260.1  phosphatase and actin regulator 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK039213, AL731783, AL772217, BC058621
      Consensus CDS
      CCDS50837.1
      UniProtKB/TrEMBL
      Q5DTG6
      Related
      ENSMUSP00000104544.2, ENSMUST00000108916.8
      Conserved Domains (1) summary
      smart00707
      Location:435 → 459
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    3. NM_001177790.1 → NP_001171261.1  phosphatase and actin regulator 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant (4) also uses an alternate in-frame splice site in the 3' coding region. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK005136, AL731783, AL772217, BC058621
      Consensus CDS
      CCDS50838.1
      UniProtKB/TrEMBL
      A2AHM4, Q5DTG6
      Related
      ENSMUSP00000104545.2, ENSMUST00000108917.8
      Conserved Domains (1) summary
      smart00707
      Location:436 → 458
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    4. NM_001177791.1 → NP_001171262.1  phosphatase and actin regulator 3 isoform 5

      See identical proteins and their annotated locations for NP_001171262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AK005136, AL731783, AL772217
      Consensus CDS
      CCDS50839.1
      UniProtKB/TrEMBL
      Q5DTG6
      Related
      ENSMUSP00000104543.2, ENSMUST00000108915.8
      Conserved Domains (1) summary
      smart00707
      Location:440 → 464
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    5. NM_028806.2 → NP_083082.1  phosphatase and actin regulator 3 isoform 1

      See identical proteins and their annotated locations for NP_083082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK135144, AL772217, BC058621
      Consensus CDS
      CCDS17158.1
      UniProtKB/Swiss-Prot
      Q8BYK5, Q8BYS8, Q8C058, Q9DB87
      UniProtKB/TrEMBL
      Q5DTG6
      Related
      ENSMUSP00000099355.4, ENSMUST00000103066.10
      Conserved Domains (2) summary
      smart00707
      Location:439 → 463
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam15345
      Location:33 → 87
      TMEM51; Transmembrane protein 51

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      177760768..177980285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500730.4 → XP_006500793.1  phosphatase and actin regulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006500793.1

      UniProtKB/TrEMBL
      Q5DTG6, Q6KCA9
      Conserved Domains (2) summary
      smart00707
      Location:399 → 423
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:353 → 506
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYK5.2 GenPept UniProtKB/Swiss-Prot:Q8BYK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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