Pf4 platelet factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pf4provided by MGI
Official Full Name: platelet factor 4provided by MGI
Primary source: MGI:MGI:1888711
See related: Ensembl:ENSMUSG00000029373 AllianceGenome:MGI:1888711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cxcl4; Scyb4
Summary: Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to protozoan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including blood vessel; bone marrow; central nervous system; liver; and yolk sac. Orthologous to several human genes including PF4 (platelet factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 119.8), liver E14.5 (RPKM 114.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.78 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (90920362..90921242)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (90772435..90773383)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-beta1/Smad2/3 signaling in mouse viral myocarditis.
Title: CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-β1/Smad2/3 signaling in mouse viral myocarditis.
Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury.
Title: Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury.
Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections.
Title: Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections.
Platelet factor 4 induces bone loss by inhibiting the integrin alpha5-FAK-ERK pathway.
Title: Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway.
Platelet factors attenuate inflammation and rescue cognition in ageing.
Title: Platelet factors attenuate inflammation and rescue cognition in ageing.
Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage.
Title: Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage.
SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
Title: SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
Platelet factor 4 is a biomarker for lymphatic-promoted disorders.
Title: Platelet factor 4 is a biomarker for lymphatic-promoted disorders.
CXCL4 promoted the production of CD4(+)CD25(+)FOXP3(+)treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway.
Title: CXCL4 promoted the production of CD4(+)CD25(+)FOXP3(+)treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway.
ELF4 binds to the promoter of genes of two C-X-C chemokines, Pf4 and pro-platelet basic protein (Ppbp), initiating the transcription of these two genes, thereby enhancing PF4-mediated killing of parasites from infected erythrocytes.
Title: ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

General gene information

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Markers

Cxcl4 (e-PCR), detects polymorphism
- UniSTS:495904

AB017491 (e-PCR)
- UniSTS:163364

PMC303331P1 (e-PCR)
- UniSTS:272490

PMC303331P3 (e-PCR)
- UniSTS:272492

RH129105 (e-PCR)
- UniSTS:212413

Pf4 (e-PCR), detects polymorphism
- UniSTS:516554

Pf4 (e-PCR), detects polymorphism
- UniSTS:516595

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CXCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet factor 4

Names: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019932.5 → NP_064316.1 platelet factor 4 precursor

See identical proteins and their annotated locations for NP_064316.1

Status: VALIDATED

Source sequence(s)

AC105995

Consensus CDS

CCDS19416.1

UniProtKB/Swiss-Prot

Q9Z126

UniProtKB/TrEMBL

Q3TVN6, Q6P8R3

Related

ENSMUSP00000031320.7, ENSMUST00000031320.8

Conserved Domains (1) summary

cd00273
Location:41 → 104

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...