Itga2b integrin alpha 2b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga2bprovided by MGI
Official Full Name: integrin alpha 2bprovided by MGI
Primary source: MGI:MGI:96601
See related: Ensembl:ENSMUSG00000034664 AllianceGenome:MGI:96601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD41; CD41B; GpIIb; alphaIIb
Summary: Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including early conceptus; genitourinary system; gut; hematopoietic system; and liver. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 19.1), liver E14.5 (RPKM 14.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 66.29 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102344134..102360570, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102453297..102469883, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHIP1 Controls Internal Platelet Contraction and alphaIIbbeta3 Integrin Dynamics in Early Platelet Activation.
Title: SHIP1 Controls Internal Platelet Contraction and α(IIb)β(3) Integrin Dynamics in Early Platelet Activation.
[Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology].
Title: [Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology].
Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice.
Title: Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice.
Knock-in mice bearing constitutively active alphaIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.
Title: Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.
Mimic chronic immune thrombocytopaenia using murine platelet induced model through immunized CD41-knockout mice.
Title: Novel Murine Model of Immune Thrombocytopaenia through Immunized CD41 Knockout Mice.
alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia.
Title: An α(II)(b) β(3) antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
Title: Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.
Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling.
Title: Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.
platelets clearly support early steps in pulmonary metastasis via GPIIb-dependent formation of platelet-tumor-aggregates
Title: Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.
ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.
Title: Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC303331P2 (e-PCR)
- UniSTS:272491

AI172977 (e-PCR)
- UniSTS:180334

Itga2b (e-PCR), detects polymorphism
- UniSTS:256442

Itga2b (e-PCR), detects polymorphism
- UniSTS:516593

PMC129049P3 (e-PCR)
- UniSTS:270583

Itga2b (e-PCR), detects polymorphism
- UniSTS:143612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables fibrinogen binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-IIb

Names: GP IIb; GPalpha IIb; alpha IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010575.3 → NP_034705.2 integrin alpha-IIb precursor

See identical proteins and their annotated locations for NP_034705.2

Status: VALIDATED

Source sequence(s)

AL596258

Consensus CDS

CCDS25500.1

UniProtKB/Swiss-Prot

Q3U3R7, Q64229, Q9QUM0, Q9Z2M0

UniProtKB/TrEMBL

B2RPR7

Related

ENSMUSP00000099375.4, ENSMUST00000103086.4

Conserved Domains (2) summary

smart00191
Location:383 → 437

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:480 → 916

Integrin_alpha2; Integrin alpha