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    Tbxas1 thromboxane A synthase 1, platelet [ Mus musculus (house mouse) ]

    Gene ID: 21391, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tbxas1provided by MGI
    Official Full Name
    thromboxane A synthase 1, plateletprovided by MGI
    Primary source
    MGI:MGI:98497
    See related
    Ensembl:ENSMUSG00000029925 AllianceGenome:MGI:98497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TS; TXS; CYP5; THAS; TXAS; CYP5A1
    Summary
    Enables thromboxane-A synthase activity. Predicted to be involved in cellular chloride ion homeostasis; positive regulation of vasoconstriction; and prostaglandin biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including bone marrow; brain; liver; lung; and metanephros. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 4.2), spleen adult (RPKM 3.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B1; 6 17.85 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38817897..39061524)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38864159..39084590)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:38676623-38676923 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38677325-38677625 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene predicted gene, 53285 Neighboring gene Hipk2R16 erythroid cis-regulatory module Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 57771 Neighboring gene predicted gene, 52859 Neighboring gene predicted gene, 23010 Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene STARR-seq mESC enhancer starr_15629 Neighboring gene lysine (K)-specific demethylase 7A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Yu IS, et al. Blood, 2004 Jul 1. PMID 15010374
    2. Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene. Zhang L, et al. Genomics, 1997 Nov 1. PMID 9367676
    3. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. Chueh TH, et al. Thromb Haemost, 2020 Feb. PMID 31785598
    4. Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury. Chiang CY, et al. Thromb Haemost, 2018 Nov. PMID 30300909
    5. Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. Pai CH, et al. PLoS One, 2016. PMID 26974824, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
      Title: Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
    2. this study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury
      Title: Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
    3. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.
      Title: Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy.
    4. 12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi
      Title: Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
    5. TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions.
      Title: Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion.
    6. thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
      Title: Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition.
    7. minimal level of protein kinase A activity is required for the steroidogenic effect of the TBXAS inhibitor and that inhibition of TBXAS activity or its expression increase the steroidogenic sensitivity of MA-10 mouse Leydig cells to cAMP stimulation
      Title: Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroperoxy icosatetraenoate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thromboxane-A synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thromboxane-A synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables thromboxane-A synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thromboxane-A synthase
    Names
    TXA synthase
    cytochrome P450 5A1
    hydroperoxy icosatetraenoate dehydratase
    thromboxane synthase
    NP_001397404.1
    NP_001397405.1
    NP_001397406.1
    NP_035669.3
    XP_006505939.1
    XP_006505942.1
    XP_006505943.1
    XP_006505944.1
    XP_011239582.1
    XP_017176988.1
    XP_017176989.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410475.1 → NP_001397404.1  thromboxane-A synthase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016

    2. NM_001410476.1 → NP_001397405.1  thromboxane-A synthase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016

    3. NM_001410477.1 → NP_001397406.1  thromboxane-A synthase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016

    4. NM_011539.4 → NP_035669.3  thromboxane-A synthase isoform 1

      See identical proteins and their annotated locations for NP_035669.3

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016
      Consensus CDS
      CCDS20018.1
      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Related
      ENSMUSP00000003017.7, ENSMUST00000003017.13
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 528
      p450; Cytochrome P450

    RNA

    1. NR_177077.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      38817897..39061524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321499.3 → XP_017176988.1  thromboxane-A synthase isoform X1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 528
      p450; Cytochrome P450

    2. XM_017321500.3 → XP_017176989.1  thromboxane-A synthase isoform X1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 528
      p450; Cytochrome P450

    3. XM_011241280.4 → XP_011239582.1  thromboxane-A synthase isoform X1

      See identical proteins and their annotated locations for XP_011239582.1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 528
      p450; Cytochrome P450

    4. XM_006505881.4 → XP_006505944.1  thromboxane-A synthase isoform X7

      UniProtKB/TrEMBL
      Q3UTF0
      Conserved Domains (1) summary
      cl12078
      Location:47 → 378
      p450; Cytochrome P450

    5. XM_006505879.5 → XP_006505942.1  thromboxane-A synthase isoform X5

      UniProtKB/TrEMBL
      Q3UTF0
      Conserved Domains (1) summary
      cl12078
      Location:47 → 455
      p450; Cytochrome P450

    6. XM_006505876.4 → XP_006505939.1  thromboxane-A synthase isoform X2

      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 528
      p450; Cytochrome P450

    7. XM_006505880.5 → XP_006505943.1  thromboxane-A synthase isoform X6

      Conserved Domains (1) summary
      pfam00067
      Location:6 → 410
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36423.2 GenPept UniProtKB/Swiss-Prot:P36423

    Gene LinkOut

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