Noxa1 NADPH oxidase activator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Noxa1provided by MGI
Official Full Name: NADPH oxidase activator 1provided by MGI
Primary source: MGI:MGI:2449980
See related: Ensembl:ENSMUSG00000036805 AllianceGenome:MGI:2449980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NY-CO-31; SDCCAG31
Summary: Enables superoxide-generating NADPH oxidase activator activity. Acts upstream of or within superoxide metabolic process. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytosol. Is expressed in pancreas and pancreas tip epithelium. Orthologous to human NOXA1 (NADPH oxidase activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 42.3), large intestine adult (RPKM 23.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.97 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24975679..24985217, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25085667..25095205, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.
Title: Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.
NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel.
Title: NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel.
Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.
Title: Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.
Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells.
Title: Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells.
Our data support an important role for NOXA1-dependent NADPH oxidase activity in VSMC plasticity during restenosis and atherosclerosis, augmenting VSMC proliferation and migration and KLF4-mediated transition to macrophage-like cells, plaque inflammation, and expansion.
Title: NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.
Title: Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
NoxA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMC) that regulates redox signaling and VSMC phenotype.
Title: Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
role in activating superoxide generation by the NADPH oxidase NOX1
Title: Two novel proteins activate superoxide generation by the NADPH oxidase NOX1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide-generating NADPH oxidase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within superoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADPH oxidase activator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163626.1 → NP_001157098.1 NADPH oxidase activator 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AK087263, AL732585

Consensus CDS

CCDS50524.1

UniProtKB/Swiss-Prot

Q8CJ00

Related

ENSMUSP00000110014.2, ENSMUST00000114373.8

Conserved Domains (5) summary

sd00006
Location:38 → 66

TPR; TPR repeat [structural motif]

pfam07719
Location:38 → 68

TPR_2; Tetratricopeptide repeat

pfam13414
Location:38 → 100

TPR_11; TPR repeat

cl02720
Location:278 → 355

PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

cl17036
Location:365 → 417

SH3; Src Homology 3 domain superfamily
NM_172204.4 → NP_757341.3 NADPH oxidase activator 1 isoform 1

See identical proteins and their annotated locations for NP_757341.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK087263, AL732585

Consensus CDS

CCDS15749.1

UniProtKB/Swiss-Prot

A2AJA1, Q80SY2, Q8BU68, Q8CJ00

Related

ENSMUSP00000037423.8, ENSMUST00000044018.8

Conserved Domains (5) summary

sd00006
Location:38 → 66

TPR; TPR repeat [structural motif]

pfam07719
Location:38 → 68

TPR_2; Tetratricopeptide repeat

pfam13414
Location:38 → 100

TPR_11; TPR repeat

cl02720
Location:286 → 363

PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

cl17036
Location:373 → 425

SH3; Src Homology 3 domain superfamily