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    Plekhs1 pleckstrin homology domain containing, family S member 1 [ Mus musculus (house mouse) ]

    Gene ID: 226245, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekhs1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family S member 1provided by MGI
    Primary source
    MGI:MGI:2443041
    See related
    Ensembl:ENSMUSG00000035818 AllianceGenome:MGI:2443041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9930023K05Rik
    Summary
    Orthologous to human PLEKHS1 (pleckstrin homology domain containing S1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 8.4), ovary adult (RPKM 3.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D2; 19 51.86 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56445705..56475161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56457275..56486729)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46523 Neighboring gene caspase 7 Neighboring gene predicted gene, 46657 Neighboring gene predicted gene, 53193 Neighboring gene DNA cross-link repair 1A Neighboring gene NHL repeat containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
      Title: PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC99964

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family S member 1
    Names
    PH domain-containing family S member 1
    PH domain-containing protein C10orf81 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164263.1 → NP_001157735.1  pleckstrin homology domain-containing family S member 1 isoform 2

      See identical proteins and their annotated locations for NP_001157735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1. Although the variants have slightly different sequences, their lengths are the same. Variant 2 encodes isoform 2, which has a slightly different sequence but is the same length as isoform 1.
      Source sequence(s)
      AC166746, AK036908
      Consensus CDS
      CCDS57148.1
      UniProtKB/Swiss-Prot
      Q8BW88
      Related
      ENSMUSP00000136674.2, ENSMUST00000178590.9
      Conserved Domains (2) summary
      pfam00169
      Location:21 → 127
      PH; PH domain
      cl17171
      Location:26 → 126
      PH-like; Pleckstrin homology-like domain

    2. NM_172641.3 → NP_766229.2  pleckstrin homology domain-containing family S member 1 isoform 1

      See identical proteins and their annotated locations for NP_766229.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC166746, AK036908, AK053921
      Consensus CDS
      CCDS29916.1
      UniProtKB/Swiss-Prot
      E9QMW0, Q5EAT4, Q8BW88, Q8BZ18, Q8R5A9
      Related
      ENSMUSP00000035440.7, ENSMUST00000039666.8
      Conserved Domains (1) summary
      cl17171
      Location:26 → 127
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      56445705..56475161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527018.3 → XP_006527081.1  pleckstrin homology domain-containing family S member 1 isoform X1

      See identical proteins and their annotated locations for XP_006527081.1

      UniProtKB/Swiss-Prot
      E9QMW0, Q5EAT4, Q8BW88, Q8BZ18, Q8R5A9
      Conserved Domains (1) summary
      cl17171
      Location:26 → 127
      PH-like; Pleckstrin homology-like domain

    2. XM_006527022.5 → XP_006527085.1  pleckstrin homology domain-containing family S member 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BW88.2 GenPept UniProtKB/Swiss-Prot:Q8BW88

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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