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    Pan3 PAN3 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 72587, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pan3provided by MGI
    Official Full Name
    PAN3 poly(A) specific ribonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1919837
    See related
    Ensembl:ENSMUSG00000029647 AllianceGenome:MGI:1919837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700050F09Rik; A430027N15Rik
    Summary
    Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.1), bladder adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G3; 5 86.93 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147363018..147485310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147426208..147548501)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14874 Neighboring gene STARR-seq mESC enhancer starr_14875 Neighboring gene STARR-positive B cell enhancer ABC_E8093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148238101-148238295 Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene predicted gene, 29793 Neighboring gene STARR-positive B cell enhancer ABC_E2773 Neighboring gene FMS-like tyrosine kinase 1 Neighboring gene predicted gene, 35383 Neighboring gene STARR-seq mESC enhancer starr_14879 Neighboring gene predicted gene, 35541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression. Zhang CL, et al. Lab Invest, 2021 Jan. PMID 32929177
    2. Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. Siddiqui N, et al. J Biol Chem, 2007 Aug 24. PMID 17595167
    3. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. Zheng D, et al. J Cell Biol, 2008 Jul 14. PMID 18625844, Free PMC Article
    4. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. Cai Y, et al. BMC Pulm Med, 2015 Jul 16. PMID 26178733, Free PMC Article
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.
      Title: CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.
    2. the poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein
      Title: Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99847, MGC102350

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytoplasmic mRNA processing body assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PAN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PAN2-PAN3 deadenylation complex subunit Pan3
    Names
    PAB-dependent poly(A)-specific ribonuclease subunit 3
    PAB1P-dependent poly(A)-specific ribonuclease
    PAN3 polyA specific ribonuclease subunit homolog
    Pabp-dependent poly(A) nuclease 3
    Pabp1-dependent poly A-specific ribonuclease subunit Pan3
    poly(A)-nuclease deadenylation complex subunit 3
    NP_001346362.1
    NP_001406711.1
    NP_001406712.1
    NP_001406713.1
    NP_001406714.1
    NP_001406715.1
    NP_001406716.1
    NP_082567.3
    XP_006504932.1
    XP_006504934.1
    XP_006504935.1
    XP_006504940.1
    XP_006504941.1
    XP_017176602.1
    XP_030110691.1
    XP_036021422.1
    XP_036021423.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359433.2 → NP_001346362.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430 → 567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181 → 349
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001419782.1 → NP_001406711.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441

    3. NM_001419783.1 → NP_001406712.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      UniProtKB/Swiss-Prot
      H3BKF3, Q3U5F2, Q640Q5, Q8CE75, Q9CZM6

    4. NM_001419784.1 → NP_001406713.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441

    5. NM_001419785.1 → NP_001406714.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441

    6. NM_001419786.1 → NP_001406715.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441

    7. NM_001419787.1 → NP_001406716.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441

    8. NM_028291.6 → NP_082567.3  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

      See identical proteins and their annotated locations for NP_082567.3

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      Consensus CDS
      CCDS39401.2
      UniProtKB/TrEMBL
      H3BJH6
      Related
      ENSMUSP00000031651.9, ENSMUST00000031651.15
      Conserved Domains (2) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl21453
      Location:439 → 607
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147363018..147485310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504872.4 → XP_006504935.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X5

      Conserved Domains (3) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:742 → 852
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:493 → 661
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017321113.2 → XP_017176602.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X6

      Conserved Domains (3) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:703 → 840
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:571 → 694
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006504869.4 → XP_006504932.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X2

      Conserved Domains (3) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:741 → 878
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:492 → 660
      PKc_like; Protein Kinases, catalytic domain

    4. XM_036165529.1 → XP_036021422.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X7

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (3) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:649 → 786
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:517 → 640
      PKc_like; Protein Kinases, catalytic domain

    5. XM_036165530.1 → XP_036021423.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430 → 567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181 → 349
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006504878.4 → XP_006504941.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X11

      UniProtKB/TrEMBL
      H3BLB9
      Conserved Domains (2) summary
      pfam18101
      Location:408 → 545
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:159 → 327
      PKc_like; Protein Kinases, catalytic domain

    7. XM_006504871.4 → XP_006504934.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X4

      Conserved Domains (3) summary
      pfam00642
      Location:55 → 74
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:718 → 855
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:469 → 637
      PKc_like; Protein Kinases, catalytic domain

    8. XM_006504877.4 → XP_006504940.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X10

      UniProtKB/TrEMBL
      H3BLB9
      Related
      ENSMUSP00000135729.2, ENSMUST00000175807.8
      Conserved Domains (2) summary
      pfam18101
      Location:411 → 548
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:162 → 330
      PKc_like; Protein Kinases, catalytic domain

    9. XM_030254831.2 → XP_030110691.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430 → 567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181 → 349
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004942572.1 RNA Sequence

    2. XR_004942573.1 RNA Sequence

    3. XR_004942570.1 RNA Sequence

    4. XR_004942571.1 RNA Sequence

    5. XR_004942574.1 RNA Sequence

    6. XR_004942575.1 RNA Sequence

      Related
      ENSMUST00000176596.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q640Q5.4 GenPept UniProtKB/Swiss-Prot:Q640Q5

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