Snx17 sorting nexin 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx17provided by MGI
Official Full Name: sorting nexin 17provided by MGI
Primary source: MGI:MGI:2387801
See related: Ensembl:ENSMUSG00000029146 AllianceGenome:MGI:2387801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0064; D5Ertd260e; b2b1625.1Clo; 5830447M19Rik
Summary: Predicted to enable low-density lipoprotein particle receptor binding activity; phosphatidylinositol binding activity; and protein C-terminus binding activity. Acts upstream of or within circulatory system development; kidney development; and receptor-mediated endocytosis. Located in endosome. Orthologous to human SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 43.6), genital fat pad adult (RPKM 40.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.26 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31350634..31356244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31193262..31198900)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX17 Mediates Dendritic Spine Maturation via p140Cap.
Title: SNX17 Mediates Dendritic Spine Maturation via p140Cap.
Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.
Title: Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
Title: Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
results identify SNX17 as a beta1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize beta1 integrins, resulting in their recycling to the cell surface where they can be reused
Title: Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.
SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes
Title: Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
results identify SNX17 as a novel adaptor protein for LDLR family members and define a novel mechanism for modulation of their endocytic activity (SNX17; sorting nexin 17)
Title: The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Ertd260e (e-PCR), detects polymorphism
- UniSTS:167426

AW990386 (e-PCR)
- UniSTS:185618

AI790646 (e-PCR)
- UniSTS:179149

ha2564 (e-PCR)
- UniSTS:515562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IPI Inferred from Physical Interaction more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: sorting nexin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418276.1 → NP_001405205.1 sorting nexin-17 isoform b

Status: VALIDATED

Source sequence(s)

AC114619
NM_001418277.1 → NP_001405206.1 sorting nexin-17 isoform c

Status: VALIDATED

Source sequence(s)

AC114619
NM_001418278.1 → NP_001405207.1 sorting nexin-17 isoform c

Status: VALIDATED

Source sequence(s)

AC114619
NM_001418279.1 → NP_001405208.1 sorting nexin-17 isoform c

Status: VALIDATED

Source sequence(s)

AC114619
NM_153680.3 → NP_710147.1 sorting nexin-17 isoform a

See identical proteins and their annotated locations for NP_710147.1

Status: VALIDATED

Source sequence(s)

AC114619

Consensus CDS

CCDS19177.1

UniProtKB/Swiss-Prot

Q8BVL3, Q8R0N8

Related

ENSMUSP00000031029.9, ENSMUST00000031029.15

Conserved Domains (3) summary

cd06885
Location:2 → 106

PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31

cd13337
Location:269 → 388

FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17

cl00155
Location:116 → 186

UBQ; Ubiquitin-like proteins