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    Aoc1l2 amine oxidase copper containing 1-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 69761, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Aoc1l2provided by MGI
    Official Full Name
    amine oxidase copper containing 1-like 2provided by MGI
    Primary source
    MGI:MGI:1917011
    See related
    Ensembl:ENSMUSG00000029813 AllianceGenome:MGI:1917011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Doxl1; 1600015I10Rik
    Summary
    Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 22.7) See more
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    Genomic context

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    Location:
    6 B2.3; 6 23.79 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48906830..48910621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48929896..48933687)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene STARR-seq mESC enhancer starr_15799 Neighboring gene amine oxidase, copper-containing 1 Neighboring gene predicted gene, 24348 Neighboring gene predicted gene 10242

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidases. Lundwall A, et al. Biol Reprod, 2003 Dec. PMID 12930721
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables primary amine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables putrescine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to antibiotic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    diamine oxidase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081273.2 → NP_001074742.2  diamine oxidase-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AI426084, BC085280, BY033750, CA539018, CF916607
      Consensus CDS
      CCDS39484.2
      UniProtKB/TrEMBL
      E9Q745, Q6IMK8
      Related
      ENSMUSP00000031837.8, ENSMUST00000031837.8
      Conserved Domains (4) summary
      PLN02566
      Location:60 → 707
      PLN02566; amine oxidase (copper-containing)
      pfam01179
      Location:308 → 707
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
      pfam02727
      Location:51 → 136
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:152 → 252
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48906830..48910621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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