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    Fam234b family with sequence similarity 234, member B [ Mus musculus (house mouse) ]

    Gene ID: 74525, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fam234bprovided by MGI
    Official Full Name
    family with sequence similarity 234, member Bprovided by MGI
    Primary source
    MGI:MGI:1921775
    See related
    Ensembl:ENSMUSG00000030207 AllianceGenome:MGI:1921775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1467; 8430419L09Rik
    Summary
    Predicted to be located in Golgi apparatus; cytoskeleton; and membrane. Predicted to be integral component of membrane. Is expressed in central nervous system and retina. Orthologous to human FAM234B (family with sequence similarity 234 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 38.0), cortex adult (RPKM 37.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G1; 6 66.02 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135173881..135213240)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135196880..135236242)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34391 Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:135168385-135168675 Neighboring gene predicted gene, 57750 Neighboring gene STARR-seq mESC enhancer starr_17565 Neighboring gene germ cell associated 1 Neighboring gene predicted gene, 36640 Neighboring gene phosphatidylethanolamine binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis. Yu X, et al. Arthritis Res Ther, 2007. PMID 17244351, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1467

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM234B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362110.1 → NP_001349039.1  protein FAM234B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC122820, AC131718
      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (1) summary
      cl11493
      Location:129 → 285
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins

    2. NM_001362111.1 → NP_001349040.1  protein FAM234B isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122820, AC131718
      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (1) summary
      TIGR03300
      Location:14 → 170
      assembly_YfgL; outer membrane assembly lipoprotein YfgL

    3. NM_028982.4 → NP_083258.2  protein FAM234B isoform 2

      See identical proteins and their annotated locations for NP_083258.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC131718, AK039401, BC079676
      Consensus CDS
      CCDS39681.1
      UniProtKB/Swiss-Prot
      Q3TE07, Q5DTX5, Q8BYI8, Q8BYJ4, Q9CXB0
      UniProtKB/TrEMBL
      B2RPZ7
      Related
      ENSMUSP00000107546.2, ENSMUST00000111915.8
      Conserved Domains (2) summary
      TIGR03300
      Location:129 → 285
      assembly_YfgL; outer membrane assembly lipoprotein YfgL
      pfam13360
      Location:186 → 473
      PQQ_2; PQQ-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      135173881..135213240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506715.4 → XP_006506778.1  protein FAM234B isoform X1

      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (2) summary
      TIGR03300
      Location:177 → 295
      assembly_YfgL; outer membrane assembly lipoprotein YfgL
      pfam13360
      Location:196 → 483
      PQQ_2; PQQ-like domain

    2. XM_030255645.2 → XP_030111505.1  protein FAM234B isoform X2

      UniProtKB/Swiss-Prot
      Q3TE07, Q5DTX5, Q8BYI8, Q8BYJ4, Q9CXB0
      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (2) summary
      TIGR03300
      Location:129 → 285
      assembly_YfgL; outer membrane assembly lipoprotein YfgL
      pfam13360
      Location:186 → 473
      PQQ_2; PQQ-like domain

    3. XM_030255647.1 → XP_030111507.1  protein FAM234B isoform X4

      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (1) summary
      TIGR03300
      Location:14 → 170
      assembly_YfgL; outer membrane assembly lipoprotein YfgL

    4. XM_030255646.1 → XP_030111506.1  protein FAM234B isoform X3

      UniProtKB/TrEMBL
      B2RPZ7
      Conserved Domains (2) summary
      TIGR03300
      Location:62 → 180
      assembly_YfgL; outer membrane assembly lipoprotein YfgL
      pfam13360
      Location:81 → 368
      PQQ_2; PQQ-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYI8.1 GenPept UniProtKB/Swiss-Prot:Q8BYI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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