Shpk sedoheptulokinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shpkprovided by MGI
Official Full Name: sedoheptulokinaseprovided by MGI
Primary source: MGI:MGI:1921887
See related: Ensembl:ENSMUSG00000005951 AllianceGenome:MGI:1921887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Carkl; 4930431K22Rik
Summary: Enables sedoheptulokinase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and pentose-phosphate shunt, non-oxidative branch. Located in cytoplasm. Is expressed in trigeminal ganglion. Orthologous to human SHPK (sedoheptulokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 14.2), duodenum adult (RPKM 6.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.25 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (73090153..73115337)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73199132..73224511)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AW260459 (e-PCR)
- UniSTS:180250

NoName (e-PCR)
- UniSTS:236632

AI194947 (e-PCR)
- UniSTS:160119

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables sedoheptulokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sedoheptulokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables sedoheptulokinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-13	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in glycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, non-oxidative branch	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sedoheptulokinase

Names: SHK; carbohydrate kinase-like protein

NP_083307.1

EC 2.7.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.