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    Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [ Mus musculus (house mouse) ]

    Gene ID: 26456, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sema4gprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gprovided by MGI
    Primary source
    MGI:MGI:1347047
    See related
    Ensembl:ENSMUSG00000025207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI507908; AW554132
    Expression
    Biased expression in colon adult (RPKM 249.8), liver adult (RPKM 161.1) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sema4g in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44976838..44991836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44988743..45003397)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45063834..45077885)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene predicted gene, 25482 Neighboring gene RIKEN cDNA 4930414N06 gene Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011976.1NP_036106.1  semaphorin-4G precursor

      See identical proteins and their annotated locations for NP_036106.1

      Status: VALIDATED

      Source sequence(s)
      AF134918
      Consensus CDS
      CCDS29853.1
      UniProtKB/Swiss-Prot
      Q9WUH7
      Related
      ENSMUSP00000026225.9, ENSMUST00000026225.15
      Conserved Domains (3) summary
      pfam01437
      Location:505555
      PSI; Plexin repeat
      cd05872
      Location:565648
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:47504
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44976838..44991836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161601.1XP_036017494.1  semaphorin-4G isoform X1

      Conserved Domains (3) summary
      pfam01437
      Location:505555
      PSI; Plexin repeat
      cd05872
      Location:565648
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:47504
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    2. XM_036161603.1XP_036017496.1  semaphorin-4G isoform X2

      Conserved Domains (3) summary
      pfam01437
      Location:237287
      PSI; Plexin repeat
      cd05872
      Location:297380
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:2236
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    3. XM_036161602.1XP_036017495.1  semaphorin-4G isoform X1

      Conserved Domains (3) summary
      pfam01437
      Location:505555
      PSI; Plexin repeat
      cd05872
      Location:565648
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:47504
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    4. XM_036161604.1XP_036017497.1  semaphorin-4G isoform X2

      Conserved Domains (3) summary
      pfam01437
      Location:237287
      PSI; Plexin repeat
      cd05872
      Location:297380
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:2236
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RNA

    1. XR_386476.4 RNA Sequence

    2. XR_386479.2 RNA Sequence

    3. XR_004940150.1 RNA Sequence

    4. XR_003952792.2 RNA Sequence

    5. XR_386477.3 RNA Sequence

    6. XR_004940151.1 RNA Sequence

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