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    Oard1 O-acyl-ADP-ribose deacylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 106821, updated on 23-Jun-2021

    Summary

    Official Symbol
    Oard1provided by MGI
    Official Full Name
    O-acyl-ADP-ribose deacylase 1provided by MGI
    Primary source
    MGI:MGI:2146818
    See related
    Ensembl:ENSMUSG00000040771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI3149; AI314976; AW558560
    Expression
    Ubiquitous expression in liver E14 (RPKM 14.3), CNS E11.5 (RPKM 13.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Oard1 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48717028..48724298)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48409957..48417270)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48549405..48556591)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables O-acetyl-ADP-ribose deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables purine nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-glutamate ADP-deribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribose glycohydrolase OARD1
    Names
    O-acetyl-ADP-ribose deacetylase 1
    [Protein ADP-ribosylglutamate] hydrolase OARD1
    terminal ADP-ribose protein glycohydrolase 1
    NP_001276419.1
    NP_001276420.1
    NP_001344832.1
    NP_001344833.1
    NP_997102.2
    XP_006523519.1
    XP_006523521.1
    XP_006523523.1
    XP_030105299.1
    XP_036016149.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289490.1NP_001276419.1  ADP-ribose glycohydrolase OARD1

      See identical proteins and their annotated locations for NP_001276419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560, BC157987, BY741306
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q8R5F3
      Related
      ENSMUSP00000130802.2, ENSMUST00000167180.8
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    2. NM_001289491.1NP_001276420.1  ADP-ribose glycohydrolase OARD1

      See identical proteins and their annotated locations for NP_001276420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    3. NM_001357903.1NP_001344832.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164
      Consensus CDS
      CCDS37647.1
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    4. NM_001357904.1NP_001344833.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AW558560, BQ553673
      Consensus CDS
      CCDS37647.1
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    5. NM_207219.4NP_997102.2  ADP-ribose glycohydrolase OARD1

      See identical proteins and their annotated locations for NP_997102.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC166164, AK153512, AW558560
      Consensus CDS
      CCDS37647.1
      UniProtKB/Swiss-Prot
      Q8R5F3
      Related
      ENSMUSP00000039280.7, ENSMUST00000046651.7
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48717028..48724298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523458.3XP_006523521.1  ADP-ribose glycohydrolase OARD1 isoform X1

      See identical proteins and their annotated locations for XP_006523521.1

      UniProtKB/Swiss-Prot
      Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    2. XM_006523456.3XP_006523519.1  ADP-ribose glycohydrolase OARD1 isoform X1

      See identical proteins and their annotated locations for XP_006523519.1

      UniProtKB/Swiss-Prot
      Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    3. XM_030249439.2XP_030105299.1  ADP-ribose glycohydrolase OARD1 isoform X2

      Conserved Domains (1) summary
      cl00019
      Location:1110
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    4. XM_036160256.1XP_036016149.1  ADP-ribose glycohydrolase OARD1 isoform X1

      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    5. XM_006523460.5XP_006523523.1  ADP-ribose glycohydrolase OARD1 isoform X1

      See identical proteins and their annotated locations for XP_006523523.1

      UniProtKB/Swiss-Prot
      Q8R5F3
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    RNA

    1. XR_004939457.1 RNA Sequence

    2. XR_004939458.1 RNA Sequence

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