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    Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 21942, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tnfrsf9provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 9provided by MGI
    Primary source
    MGI:MGI:1101059
    See related
    Ensembl:ENSMUSG00000028965 AllianceGenome:MGI:1101059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILA; Ly63; 4-1BB; Cd137; CDw137; A930040I11Rik
    Summary
    Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 139.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 81.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (151004612..151030561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150920155..150946104)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene STARR-positive B cell enhancer ABC_E10293 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:150271076-150271277 Neighboring gene STARR-seq mESC enhancer starr_12178 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene STARR-positive B cell enhancer ABC_E2733 Neighboring gene STARR-positive B cell enhancer ABC_E6289 Neighboring gene predicted gene, 23405 Neighboring gene predicted gene, 30120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice. Han J, et al. Front Endocrinol (Lausanne), 2022. PMID 35846320, Free PMC Article
    2. CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation. Otano I, et al. Nat Commun, 2021 Dec 15. PMID 34911975, Free PMC Article
    3. Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission. Xu Y, et al. Int J Biochem Cell Biol, 2021 Jul. PMID 33971320
    4. Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice. Wan D, et al. Exp Mol Med, 2021 Apr. PMID 33859350, Free PMC Article
    5. Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation. Kamata-Sakurai M, et al. Cancer Discov, 2021 Jan. PMID 32847940

    See all (237) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma.
      Title: Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma.
    2. CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE[-/-] Mice Via Rab7-Mediated Autophagy.
      Title: CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE(-/-) Mice Via Rab7-Mediated Autophagy.
    3. CD137 Regulates Bone Loss via the p53 Wnt/beta-Catenin Signaling Pathways in Aged Mice.
      Title: CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice.
    4. Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice.
      Title: Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice.
    5. EZH2 Inhibition Compromises alpha4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8(+) T Cells.
      Title: EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8(+) T Cells.
    6. CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation.
      Title: CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation.
    7. Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
      Title: Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
    8. CD137 costimulation enhances the antiviral activity of Vgamma9Vdelta2-T cells against influenza virus.
      Title: CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus.
    9. Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway.
      Title: Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway.
    10. Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission.
      Title: Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission.
    Submit: New GeneRIF Correction See all GeneRIFs (143)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of immature T cell proliferation in thymus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 9
    Names
    4-1BB ligand receptor
    CD137 antigen
    T-cell antigen 4-1BB
    secreted CD137 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077508.1 → NP_001070976.1  tumor necrosis factor receptor superfamily member 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is a soluble form that lacks the transmembrane domain.
      Source sequence(s)
      AK019885, BC028507, BY206772, BY539760
      Consensus CDS
      CCDS38980.1
      UniProtKB/TrEMBL
      A2A887, Q8R037
      Related
      ENSMUSP00000101297.4, ENSMUST00000105672.10
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    2. NM_001077509.1 → NP_001070977.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK019885, BY196142, BY539760
      Consensus CDS
      CCDS18976.1
      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      A2A888, Q3U3R1
      Related
      ENSMUSP00000111961.2, ENSMUST00000116257.8
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    3. NM_011612.2 → NP_035742.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK019885, BY206772, BY539760
      Consensus CDS
      CCDS18976.1
      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      A2A888, Q3U3R1
      Related
      ENSMUSP00000030808.4, ENSMUST00000030808.10
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      151004612..151030561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250228.3 → XP_011248530.1  tumor necrosis factor receptor superfamily member 9 isoform X1

      See identical proteins and their annotated locations for XP_011248530.1

      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      A2A888, Q3U3R1
      Related
      ENSMUSP00000101296.2, ENSMUST00000105671.8
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20334.1 GenPept UniProtKB/Swiss-Prot:P20334

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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