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    Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 21942, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tnfrsf9provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 9provided by MGI
    Primary source
    MGI:MGI:1101059
    See related
    Ensembl:ENSMUSG00000028965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILA; Ly6; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
    Expression
    Restricted expression toward placenta adult (RPKM 139.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnfrsf9 in Genome Data Viewer
    Location:
    4 E2; 4 81.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (151004612..151030561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150920155..150946104)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150294264..150320211)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene predicted gene, 23405 Neighboring gene predicted gene, 30120

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 9
    Names
    4-1BB ligand receptor
    CD137 antigen
    T-cell antigen 4-1BB
    secreted CD137 antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077508.1NP_001070976.1  tumor necrosis factor receptor superfamily member 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is a soluble form that lacks the transmembrane domain.
      Source sequence(s)
      AK019885, BC028507, BY206772, BY539760
      Consensus CDS
      CCDS38980.1
      UniProtKB/TrEMBL
      Q8R037
      Related
      ENSMUSP00000101297.4, ENSMUST00000105672.10
      Conserved Domains (1) summary
      cd13410
      Location:23160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
    2. NM_001077509.1NP_001070977.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK019885, BY196142, BY539760
      Consensus CDS
      CCDS18976.1
      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      Q3U3R1
      Related
      ENSMUSP00000111961.2, ENSMUST00000116257.8
      Conserved Domains (1) summary
      cd13410
      Location:23160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
    3. NM_011612.2NP_035742.1  tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK019885, BY206772, BY539760
      Consensus CDS
      CCDS18976.1
      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      Q3U3R1
      Related
      ENSMUSP00000030808.4, ENSMUST00000030808.10
      Conserved Domains (1) summary
      cd13410
      Location:23160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      151004612..151030561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250228.3XP_011248530.1  tumor necrosis factor receptor superfamily member 9 isoform X1

      See identical proteins and their annotated locations for XP_011248530.1

      UniProtKB/Swiss-Prot
      P20334
      UniProtKB/TrEMBL
      Q3U3R1
      Related
      ENSMUSP00000101296.2, ENSMUST00000105671.8
      Conserved Domains (1) summary
      cd13410
      Location:23160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
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