Actr3 ARP3 actin-related protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Actr3provided by MGI
Official Full Name: ARP3 actin-related protein 3provided by MGI
Primary source: MGI:MGI:1921367
See related: Ensembl:ENSMUSG00000026341 AllianceGenome:MGI:1921367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arp3; 1200003A09Rik
Summary: Predicted to enable ATPase binding activity and actin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in brush border; cell-cell junction; and lamellipodium. Is expressed in several structures, including alimentary system; blastocyst; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 60.4), CNS E14 (RPKM 36.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 54.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (125320642..125363464, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (125392905..125435727, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification.
Title: Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification.
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
Title: Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic beta cells to control insulin secretion.
Title: Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion.
The actin foci are generated by Arp2/3-mediated branched-actin polymerization and stochastically associate with antigen clusters to mediate internalization.
Title: B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments.
The finding that Arp2/3 complex activity is important for B cell responses to spatially restricted membrane-bound antigens, but not for soluble antigens, highlights a critical role for Arp2/3 complex-dependent actin remodeling in B cell responses to antigen-presenting cell-bound antigens.
Title: Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation.
We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes
Title: The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.
Arp2 and Arp3 expression was increased under atherosclerotic conditions both in ApoE-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
Title: ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression.
possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability.
Title: Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.
demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
Title: Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
Title: Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within asymmetric cell division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic chromosome movement towards spindle pole	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of myosin II filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle localization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
located_in apical ectoplasmic specialization	ISO Inferred from Sequence Orthology more info
part_of apical tubulobulbar complex	ISO Inferred from Sequence Orthology more info
located_in basal ectoplasmic specialization	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in concave side of sperm head	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in leading edge of lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in podosome core	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-related protein 3

Names: ARP3 actin-related protein 3 homolog; actin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205385.1 → NP_001192314.1 actin-related protein 3

See identical proteins and their annotated locations for NP_001192314.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC124528, AC166158

Consensus CDS

CCDS15242.1

UniProtKB/Swiss-Prot

Q99JY9, Q9DC56

UniProtKB/TrEMBL

Q3TGW0, Q3TWJ4, Q3ULF7

Related

ENSMUSP00000027579.11, ENSMUST00000027579.17

Conserved Domains (1) summary

PTZ00280
Location:2 → 417

PTZ00280; Actin-related protein 3; Provisional
NM_001205386.1 → NP_001192315.1 actin-related protein 3

See identical proteins and their annotated locations for NP_001192315.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC124528, AK166529, AV137086

Consensus CDS

CCDS15242.1

UniProtKB/Swiss-Prot

Q99JY9, Q9DC56

UniProtKB/TrEMBL

Q3TGW0, Q3TWJ4, Q3ULF7

Conserved Domains (1) summary

PTZ00280
Location:2 → 417

PTZ00280; Actin-related protein 3; Provisional
NM_023735.2 → NP_076224.1 actin-related protein 3

See identical proteins and their annotated locations for NP_076224.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC124528, AK145536, AV137086

Consensus CDS

CCDS15242.1

UniProtKB/Swiss-Prot

Q99JY9, Q9DC56

UniProtKB/TrEMBL

Q3TGW0, Q3TWJ4, Q3ULF7

Related

ENSMUSP00000137503.2, ENSMUST00000178474.8

Conserved Domains (1) summary

PTZ00280
Location:2 → 417

PTZ00280; Actin-related protein 3; Provisional