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    Igf1 insulin-like growth factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16000, updated on 23-Oct-2021

    Summary

    Official Symbol
    Igf1provided by MGI
    Official Full Name
    insulin-like growth factor 1provided by MGI
    Primary source
    MGI:MGI:96432
    See related
    Ensembl:ENSMUSG00000020053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igf-1; Igf-I; C730016P09Rik
    Summary
    This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in liver adult (RPKM 36.1), subcutaneous fat pad adult (RPKM 12.7) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Igf1 in Genome Data Viewer
    Location:
    10 C1; 10 43.7 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (87694127..87772909)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (87858265..87937047)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (87321801..87399792)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30073 Neighboring gene nuclear encoded tRNA lysine 21 (anticodon TTT) Neighboring gene insulin-like growth factor 1, opposite strand Neighboring gene VISTA enhancer mm694 Neighboring gene thymidylate synthase, pseudogene Neighboring gene predicted gene, 30233

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone mineralization involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung lobe morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung lobe morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myotube cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cholangiocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of immune system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oligodendrocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myelination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of steroid hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of trophectodermal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland stromal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of smell TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within type I pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within type II pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within water homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of insulin-like growth factor ternary complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of insulin-like growth factor ternary complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor I
    Names
    somatomedin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111274.1NP_001104744.1  insulin-like growth factor I isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (3) with a novel N-terminus, compared to isoform 1. This isoform (3) is also known as IIB. This isoform (3) may undergo proteolytic processing similar to isoform 4.
      Source sequence(s)
      AC139754, AK038119, CT010364
      Consensus CDS
      CCDS48662.1
      UniProtKB/TrEMBL
      E9PU89, Q8CAR0
      Related
      ENSMUSP00000112878.2, ENSMUST00000122100.3
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    2. NM_001111275.2NP_001104745.1  insulin-like growth factor I isoform 4 preproprotein

      See identical proteins and their annotated locations for NP_001104745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.
      Source sequence(s)
      AC125082, AC139754, AK081019
      Consensus CDS
      CCDS48661.1
      UniProtKB/Swiss-Prot
      P05017
      UniProtKB/TrEMBL
      Q4VJC0
      Related
      ENSMUSP00000093005.5, ENSMUST00000095360.11
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    3. NM_001111276.1NP_001104746.1  insulin-like growth factor I isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (5) with novel N- and C-termini, compared to isoform 1. This isoform (5) is also known as IIA. This isoform (5) may undergo proteolytic processing similar to isoform 4.
      Source sequence(s)
      AC139754, AK038119, CT010364
      Consensus CDS
      CCDS48663.1
      UniProtKB/TrEMBL
      E9Q138, Q8CAR0
      Related
      ENSMUSP00000114120.2, ENSMUST00000121161.8
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    4. NM_001314010.1NP_001300939.1  insulin-like growth factor I isoform 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.
      Source sequence(s)
      AC125082, AC139754, AK081019
      Consensus CDS
      CCDS48661.1
      UniProtKB/Swiss-Prot
      P05017
      UniProtKB/TrEMBL
      Q4VJC0
      Related
      ENSMUSP00000113905.2, ENSMUST00000122386.8
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    5. NM_010512.5NP_034642.2  insulin-like growth factor I isoform 1

      See identical proteins and their annotated locations for NP_034642.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) is also known as IB. This isoform (1) may undergo proteolytic processing similar to isoform 4.
      Source sequence(s)
      AC125082, AC139754, AI019109, AK081019
      Consensus CDS
      CCDS24104.2
      UniProtKB/Swiss-Prot
      P05017
      UniProtKB/TrEMBL
      Q4VJB9
      Related
      ENSMUSP00000100937.3, ENSMUST00000105300.9
      Conserved Domains (1) summary
      cd04368
      Location:49116
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      87694127..87772909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244906.1XP_030100766.1  insulin-like growth factor I isoform X4

      Conserved Domains (1) summary
      cd04368
      Location:64131
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    2. XM_006513264.4XP_006513327.1  insulin-like growth factor I isoform X10

      Conserved Domains (1) summary
      cd04368
      Location:34101
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    3. XM_030244911.1XP_030100771.1  insulin-like growth factor I isoform X12

      Conserved Domains (1) summary
      cd04368
      Location:34101
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    4. XM_006513257.1XP_006513320.1  insulin-like growth factor I isoform X2

      See identical proteins and their annotated locations for XP_006513320.1

      Conserved Domains (1) summary
      cd04368
      Location:87154
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    5. XM_006513255.3XP_006513318.1  insulin-like growth factor I isoform X1

      See identical proteins and their annotated locations for XP_006513318.1

      Conserved Domains (1) summary
      cd04368
      Location:87154
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    6. XM_030244907.1XP_030100767.1  insulin-like growth factor I isoform X5

      Conserved Domains (1) summary
      cd04368
      Location:64131
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    7. XM_006513258.3XP_006513321.1  insulin-like growth factor I isoform X6

      Conserved Domains (1) summary
      cd04368
      Location:57124
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    8. XM_030244908.2XP_030100768.1  insulin-like growth factor I isoform X7

      Conserved Domains (1) summary
      cd04368
      Location:57124
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    9. XM_030244910.1XP_030100770.1  insulin-like growth factor I isoform X9

      Conserved Domains (1) summary
      cd04368
      Location:46113
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    10. XM_006513262.3XP_006513325.1  insulin-like growth factor I isoform X8

      Conserved Domains (1) summary
      cd04368
      Location:46113
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    11. XM_017313810.2XP_017169299.1  insulin-like growth factor I isoform X3

      Conserved Domains (1) summary
      cd04368
      Location:76143
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    12. XM_017313812.3XP_017169301.1  insulin-like growth factor I isoform X11

      UniProtKB/TrEMBL
      E9PU89
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    13. XM_017313811.1XP_017169300.1  insulin-like growth factor I isoform X11

      UniProtKB/TrEMBL
      E9PU89
      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    14. XM_030244912.2XP_030100772.1  insulin-like growth factor I isoform X13

      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    15. XM_036155648.1XP_036011541.1  insulin-like growth factor I isoform X11

      Conserved Domains (1) summary
      cd04368
      Location:33100
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_184052.3: Suppressed sequence

      Description
      NM_184052.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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