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    Epha8 Eph receptor A8 [ Mus musculus (house mouse) ]

    Gene ID: 13842, updated on 16-Oct-2021

    Summary

    Official Symbol
    Epha8provided by MGI
    Official Full Name
    Eph receptor A8provided by MGI
    Primary source
    MGI:MGI:109378
    See related
    Ensembl:ENSMUSG00000028661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eek; Hek3; AW047546; mKIAA1459
    Expression
    Biased expression in cerebellum adult (RPKM 13.1), CNS E18 (RPKM 11.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Epha8 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136656729..136684170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136929419..136956859, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136485334..136512731, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent, C chain Neighboring gene complement component 1, q subcomponent, alpha polypeptide Neighboring gene zinc finger and BTB domain containing 40 Neighboring gene predicted gene, 23834 Neighboring gene predicted gene, 31648

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1459

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substrate-dependent cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ephrin type-A receptor 8
    Names
    EPH- and ELK-related kinase
    Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase)
    tyrosine-protein kinase receptor EEK
    NP_031965.2
    XP_030109047.1
    XP_030109049.1
    XP_036019550.1
    XP_036019551.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007939.2NP_031965.2  ephrin type-A receptor 8 precursor

      See identical proteins and their annotated locations for NP_031965.2

      Status: VALIDATED

      Source sequence(s)
      AL627214, U72207
      Consensus CDS
      CCDS18813.1
      UniProtKB/Swiss-Prot
      O09127
      Related
      ENSMUSP00000030420.9, ENSMUST00000030420.9
      Conserved Domains (8) summary
      cd09550
      Location:932994
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:933993
      SAM; Sterile alpha motif
      cd10486
      Location:30202
      EphR_LBD_A8; Ligand Binding Domain of Ephrin type-A Receptor 8
      cd00063
      Location:439530
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:329422
      fn3; Fibronectin type III domain
      pfam07714
      Location:634891
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:565629
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:629895
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136656729..136684170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163657.1XP_036019550.1  ephrin type-A receptor 8 isoform X1

      Conserved Domains (4) summary
      cd09550
      Location:930992
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd10486
      Location:30202
      EphR_LBD_A8; Ligand Binding Domain of Ephrin type-A Receptor 8
      pfam00041
      Location:438521
      fn3; Fibronectin type III domain
      cl21453
      Location:627893
      PKc_like; Protein Kinases, catalytic domain
    2. XM_030253189.2XP_030109049.1  ephrin type-A receptor 8 isoform X3

      Conserved Domains (4) summary
      cd09550
      Location:450512
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd00063
      Location:1148
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam14575
      Location:83147
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:147413
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036163658.1XP_036019551.1  ephrin type-A receptor 8 isoform X2

      Conserved Domains (5) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:555821
      PKc_like; Protein Kinases, catalytic domain
    4. XM_030253187.2XP_030109047.1  ephrin type-A receptor 8 isoform X2

      Conserved Domains (5) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:555821
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004941809.1 RNA Sequence

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