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    Spdye4b speedy/RINGO cell cycle regulator family, member E4B [ Mus musculus (house mouse) ]

    Gene ID: 330228, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Spdye4bprovided by MGI
    Official Full Name
    speedy/RINGO cell cycle regulator family, member E4Bprovided by MGI
    Primary source
    MGI:MGI:3612701
    See related
    Ensembl:ENSMUSG00000029586 AllianceGenome:MGI:3612701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933411G11Rik
    Summary
    Predicted to enable protein kinase binding activity. Is expressed in testis and thyroid gland. Orthologous to several human genes including SPDYE4 (speedy/RINGO cell cycle regulator family member E4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 6.9) See more
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    Genomic context

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    See Spdye4b in Genome Data Viewer
    Location:
    5 G2; 5 81.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143166772..143190832)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143181017..143205077)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RB-associated KRAB zinc finger downstream neighbor (non-protein coding) Neighboring gene RB-associated KRAB zinc finger Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143942516-143942699 Neighboring gene speedy/RINGO cell cycle regulator family, member E4A Neighboring gene RIKEN cDNA 4930448H16 gene Neighboring gene predicted gene, 38735

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    speedy/RINGO cell cycle regulator family, member E4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384193.1 → NP_001371122.1  speedy/RINGO cell cycle regulator family, member E4B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123686
      Conserved Domains (1) summary
      pfam11357
      Location:94 → 223
      Spy1; Cell cycle regulatory protein

    2. NM_177880.4 → NP_808548.1  speedy/RINGO cell cycle regulator family, member E4B isoform 2

      See identical proteins and their annotated locations for NP_808548.1

      Status: PROVISIONAL

      Source sequence(s)
      AC123686
      Consensus CDS
      CCDS51688.1
      UniProtKB/TrEMBL
      Q8CDE8
      Related
      ENSMUSP00000031574.4, ENSMUST00000031574.10
      Conserved Domains (1) summary
      pfam11357
      Location:87 → 213
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143166772..143190832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504715.5 → XP_006504778.1  speedy/RINGO cell cycle regulator family, member E4B isoform X1

      See identical proteins and their annotated locations for XP_006504778.1

      UniProtKB/TrEMBL
      Q8CDE8
      Conserved Domains (1) summary
      pfam11357
      Location:87 → 213
      Spy1; Cell cycle regulatory protein
    Nucleotide Protein Strain
    Heading Accession and Version

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