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    Ctdsp2 CTD small phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 52468, updated on 12-Mar-2024

    Summary

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    Official Symbol
    Ctdsp2provided by MGI
    Official Full Name
    CTD small phosphatase 2provided by MGI
    Primary source
    MGI:MGI:1098748
    See related
    Ensembl:ENSMUSG00000078429 AllianceGenome:MGI:1098748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OS4; OS-4; SCP2; D10Ertd73e
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; integumental system; respiratory system; and tail. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 75.2), limb E14.5 (RPKM 74.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D3; 10 74.35 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126814586..126835844)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (126978717..126999975)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30539 Neighboring gene STARR-seq mESC enhancer starr_28199 Neighboring gene STARR-positive B cell enhancer ABC_E3925 Neighboring gene predicted gene, 40798 Neighboring gene microRNA 26a-2 Neighboring gene microRNA 546 Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Kloet DE, et al. Biochem J, 2015 Jul 15. PMID 25990325, Free PMC Article
    2. Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex. Zhang H, et al. Front Mol Neurosci, 2018. PMID 29515367, Free PMC Article
    3. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Zhu Y, et al. Nucleic Acids Res, 2012 May. PMID 22210897, Free PMC Article
    4. Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. Bolt CC, et al. PLoS One, 2016. PMID 27120339, Free PMC Article
    5. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras.
      Title: FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38258

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
    nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4)
    small C-terminal domain phosphatase 2
    NP_001106941.1
    NP_666124.1
    XP_036011783.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113470.1 → NP_001106941.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a

      See identical proteins and their annotated locations for NP_001106941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK049271, BB731474, BC085142
      Consensus CDS
      CCDS48711.1
      UniProtKB/Swiss-Prot
      Q8BX07
      Related
      ENSMUSP00000100891.3, ENSMUST00000105256.10
      Conserved Domains (1) summary
      TIGR02251
      Location:100 → 259
      HIF-SF_euk; Dullard-like phosphatase domain

    2. NM_146012.2 → NP_666124.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform b

      See identical proteins and their annotated locations for NP_666124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA103008, AK049271, BB731474, CB527995
      Consensus CDS
      CCDS36076.1
      UniProtKB/TrEMBL
      Q8R3B3
      Related
      ENSMUSP00000100890.3, ENSMUST00000105255.3
      Conserved Domains (1) summary
      cl21460
      Location:1 → 108
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126814586..126835844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155890.1 → XP_036011783.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform X1

      Conserved Domains (1) summary
      TIGR02251
      Location:87 → 246
      HIF-SF_euk; Dullard-like phosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX07.1 GenPept UniProtKB/Swiss-Prot:Q8BX07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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