Vamp7 vesicle-associated membrane protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vamp7provided by MGI
Official Full Name: vesicle-associated membrane protein 7provided by MGI
Primary source: MGI:MGI:1096399
See related: AllianceGenome:MGI:1096399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sybl1; VAMP-7; TI-VAMP
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly and positive regulation of dendrite morphogenesis. Acts upstream of or within Golgi to plasma membrane protein transport and regulation of protein targeting to vacuolar membrane. Located in several cellular components, including cytoplasmic vesicle; lamellipodium; and pseudopodium. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: chromosome: X

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X Unlocalized Scaffold	NT_165789.3 (105706..134151, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X Unlocalized Scaffold	NT_165789.2 (10737..39191, complement)

NT_165789.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells.
Title: VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells.
Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons.
Title: Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons.
VAMP7 participates in autophagosome formation by supporting Atg9a functions that contribute to maintenance of mitochondrial quality.
Title: VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice.
Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons.
Title: Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons.
VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step.
Title: BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.
VAMP7-mediated release of interleukin-12 at the immune synapse is a mechanism to transmit innate signals to T cells.
Title: The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells.
VAMP7 mediates plasma membrane fusion of vesicles containing TRPM8. VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity.
Title: VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
VAMP-7(-/-) platelets demonstrated a partial defect in dense granule exocytosis and impaired aggregation. Consistent with a role in cytoskeletal remodeling, spreading on matrices was decreased in VAMP-7(-/-) platelets compared to wild-type controls.
Title: VAMP-7 links granule exocytosis to actin reorganization during platelet activation.
syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes
Title: Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.
VAMP7 controls the phosphorylation of Lat, formation of the TCR-Lat signaling complex and, ultimately, activation of T cells.
Title: VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sybl1 (e-PCR), detects polymorphism
- UniSTS:144527

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in eosinophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in eosinophil degranulation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil degranulation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein targeting to vacuolar membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle fusion with Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in azurophil granule membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vesicle-associated membrane protein 7

Names: synaptobrevin like 1; tetanus neurotoxin-insensitive vesicle-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302138.2 → NP_001289067.1 vesicle-associated membrane protein 7 isoform 2

See identical proteins and their annotated locations for NP_001289067.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

FO907127

Conserved Domains (2) summary

cd15871
Location:85 → 149

R-SNARE_VAMP7; SNARE motif of VAMP7

cd14824
Location:10 → 77

Longin; longin domain
NM_001359151.2 → NP_001346080.1 vesicle-associated membrane protein 7 isoform 3

Status: VALIDATED

Source sequence(s)

FO907127

Conserved Domains (1) summary

cd15871
Location:23 → 87

R-SNARE_VAMP7; SNARE motif of VAMP7
NM_011515.6 → NP_035645.1 vesicle-associated membrane protein 7 isoform 1

See identical proteins and their annotated locations for NP_035645.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

FO907127

UniProtKB/Swiss-Prot

P70280

Conserved Domains (2) summary

cd15871
Location:124 → 188

R-SNARE_VAMP7; SNARE motif of VAMP7

pfam13774
Location:29 → 104

Longin; Regulated-SNARE-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NT_165789.3 Reference GRCm39 C57BL/6J

Range

105706..134151 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249809.4 → XP_011248111.1 vesicle-associated membrane protein 7 isoform X1

See identical proteins and their annotated locations for XP_011248111.1

Conserved Domains (2) summary

cd15871
Location:85 → 149

R-SNARE_VAMP7; SNARE motif of VAMP7

cd14824
Location:10 → 77

Longin; longin domain