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    Sergef secretion regulating guanine nucleotide exchange factor [ Mus musculus (house mouse) ]

    Gene ID: 27414, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sergefprovided by MGI
    Official Full Name
    secretion regulating guanine nucleotide exchange factorprovided by MGI
    Primary source
    MGI:MGI:1351630
    See related
    Ensembl:ENSMUSG00000030839 AllianceGenome:MGI:1351630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gef; Gnef; Gnefr; DelGEF
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of protein secretion. Located in cytoplasm and nucleus. Is expressed in central nervous system; esophagus; and ganglia. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.3), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 30.2 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46092583..46289254, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46443159..46642896, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9691 Neighboring gene myogenic differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4927 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 1 Neighboring gene predicted gene, 22969 Neighboring gene STARR-seq mESC enhancer starr_18863 Neighboring gene STARR-seq mESC enhancer starr_18865 Neighboring gene STARR-seq mESC enhancer starr_18866 Neighboring gene STARR-seq mESC enhancer starr_18867 Neighboring gene tryptophan hydroxylase 1 Neighboring gene serum amyloid A-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. Takenaka N, et al. PLoS One, 2016. PMID 27163697, Free PMC Article
    2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. Uhlmann J, et al. FEBS Lett, 1999 Oct 22. PMID 10571079
    3. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Zhang Q, et al. Nat Genet, 2003 Feb. PMID 12548288
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor FLJ00068 in Akt2-mediated insulin signaling in mouse skeletal muscle.
      Title: Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141208, MGC141209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretion-regulating guanine nucleotide exchange factor
    Names
    deafness locus-associated putative guanine nucleotide exchange factor
    guanine nucleotide exchange factor (RCC1 related)
    guanine nucleotide exchange factor-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013789.2 → NP_038817.1  secretion-regulating guanine nucleotide exchange factor

      See identical proteins and their annotated locations for NP_038817.1

      Status: VALIDATED

      Source sequence(s)
      AC090652, AK145819, BY228093
      Consensus CDS
      CCDS21279.1
      UniProtKB/Swiss-Prot
      Q0VDT0, Q3UGM8, Q3UKY0, Q80YD6, Q9QXB7
      Related
      ENSMUSP00000033127.5, ENSMUST00000033127.12
      Conserved Domains (2) summary
      pfam00415
      Location:17 → 64
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:103 → 132
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46092583..46289254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153151.1 → XP_036009044.1  secretion-regulating guanine nucleotide exchange factor isoform X2

      Conserved Domains (2) summary
      COG5184
      Location:17 → 348
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:334 → 380
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. XM_030242640.2 → XP_030098500.1  secretion-regulating guanine nucleotide exchange factor isoform X8

      Conserved Domains (1) summary
      COG5184
      Location:17 → 279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. XM_006540943.5 → XP_006541006.1  secretion-regulating guanine nucleotide exchange factor isoform X1

      Conserved Domains (2) summary
      COG5184
      Location:22 → 370
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:356 → 402
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    4. XM_011250869.2 → XP_011249171.1  secretion-regulating guanine nucleotide exchange factor isoform X5

      See identical proteins and their annotated locations for XP_011249171.1

      Conserved Domains (2) summary
      COG5184
      Location:2 → 255
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:241 → 287
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    5. XM_006540944.4 → XP_006541007.1  secretion-regulating guanine nucleotide exchange factor isoform X5

      See identical proteins and their annotated locations for XP_006541007.1

      Conserved Domains (2) summary
      COG5184
      Location:2 → 255
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:241 → 287
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    6. XM_030242642.2 → XP_030098502.1  secretion-regulating guanine nucleotide exchange factor isoform X10

      Conserved Domains (1) summary
      COG5184
      Location:17 → 258
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    7. XM_036153152.1 → XP_036009045.1  secretion-regulating guanine nucleotide exchange factor isoform X4

      Conserved Domains (1) summary
      COG5184
      Location:17 → 327
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    8. XM_030242641.2 → XP_030098501.1  secretion-regulating guanine nucleotide exchange factor isoform X9

      Conserved Domains (1) summary
      COG5184
      Location:17 → 279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    9. XM_030242638.2 → XP_030098498.1  secretion-regulating guanine nucleotide exchange factor isoform X3

      UniProtKB/TrEMBL
      A0A1L1SUM5
      Related
      ENSMUSP00000150835.2, ENSMUST00000216505.2
      Conserved Domains (1) summary
      COG5184
      Location:17 → 348
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    10. XM_036153153.1 → XP_036009046.1  secretion-regulating guanine nucleotide exchange factor isoform X7

      Conserved Domains (1) summary
      COG5184
      Location:17 → 258
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    11. XM_030242639.2 → XP_030098499.1  secretion-regulating guanine nucleotide exchange factor isoform X6

      Conserved Domains (1) summary
      COG5184
      Location:17 → 279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RNA

    1. XR_003946486.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YD6.2 GenPept UniProtKB/Swiss-Prot:Q80YD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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