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    Clasrp CLK4-associating serine/arginine rich protein [ Mus musculus (house mouse) ]

    Gene ID: 53609, updated on 5-Mar-2024

    Summary

    Official Symbol
    Clasrpprovided by MGI
    Official Full Name
    CLK4-associating serine/arginine rich proteinprovided by MGI
    Primary source
    MGI:MGI:1855695
    See related
    Ensembl:ENSMUSG00000061028 AllianceGenome:MGI:1855695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clasp; Swap2; Sfrs16; Srsf16
    Summary
    The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 41.1), limb E14.5 (RPKM 37.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    7 A3; 7 9.93 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19314963..19338442, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19581038..19604517, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18207 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene zinc finger protein 296 Neighboring gene avian reticuloendotheliosis viral (v-rel) oncogene related B Neighboring gene STARR-positive B cell enhancer ABC_E1720 Neighboring gene cleft lip and palate associated transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118002

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CLK4-associating serine/arginine rich protein
    Names
    Clk4 associating SR-related protein
    serine/arginine-rich splicing factor 16
    splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)
    suppressor of white-apricot homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016680.5NP_057889.3  CLK4-associating serine/arginine rich protein

      See identical proteins and their annotated locations for NP_057889.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (L, PMID:12169693) represents the shortest transcript and encodes the protein.
      Source sequence(s)
      BC051916, BC060092, CJ146179
      Consensus CDS
      CCDS52061.1
      UniProtKB/Swiss-Prot
      Q5RKW4, Q8CFC7, Q8CFC8, Q9Z2N3
      Related
      ENSMUSP00000083205.6, ENSMUST00000086041.7
      Conserved Domains (1) summary
      pfam09750
      Location:41169
      DRY_EERY; Alternative splicing regulator

    RNA

    1. NR_125832.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (S, PMID: 12169693) uses an alternate splice site in an internal exon, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC051916, BC060092, CJ146179
      Related
      ENSMUST00000208068.2
    2. NR_125833.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in its internal exons, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC051916, BC060092, BC103781, BY591198, CJ146179
      Related
      ENSMUST00000207524.2
    3. NR_125834.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon segment, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK009334, BC051916, BC060092, CJ146179
    4. NR_125835.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon and contains an alternate internal exon segment, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF042799, BC060092
      Related
      ENSMUST00000207907.2
    5. NR_125836.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in its internal exons, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC060092, BC103781, CJ146179
      Related
      ENSMUST00000207663.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19314963..19338442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242772.1XP_030098632.1  CLK4-associating serine/arginine rich protein isoform X3

      Conserved Domains (1) summary
      pfam09750
      Location:41169
      DRY_EERY; Alternative splicing regulator
    2. XM_011250629.1XP_011248931.1  CLK4-associating serine/arginine rich protein isoform X2

      Conserved Domains (1) summary
      pfam09750
      Location:41169
      DRY_EERY; Alternative splicing regulator
    3. XM_017322361.1XP_017177850.1  CLK4-associating serine/arginine rich protein isoform X1

      Conserved Domains (1) summary
      pfam09750
      Location:41169
      DRY_EERY; Alternative splicing regulator
    4. XM_036153245.1XP_036009138.1  CLK4-associating serine/arginine rich protein isoform X8

    5. XM_017322362.3XP_017177851.1  CLK4-associating serine/arginine rich protein isoform X7

    6. XM_030242774.1XP_030098634.1  CLK4-associating serine/arginine rich protein isoform X5

      Conserved Domains (1) summary
      pfam09750
      Location:4107
      DRY_EERY; Alternative splicing regulator
    7. XM_030242773.1XP_030098633.1  CLK4-associating serine/arginine rich protein isoform X4

      Conserved Domains (1) summary
      pfam09750
      Location:4107
      DRY_EERY; Alternative splicing regulator
    8. XM_030242778.1XP_030098638.1  CLK4-associating serine/arginine rich protein isoform X7

    9. XM_030242779.1XP_030098639.1  CLK4-associating serine/arginine rich protein isoform X8

    10. XM_030242776.1XP_030098636.1  CLK4-associating serine/arginine rich protein isoform X7

    11. XM_036153242.1XP_036009135.1  CLK4-associating serine/arginine rich protein isoform X7

    12. XM_030242775.2XP_030098635.1  CLK4-associating serine/arginine rich protein isoform X6

      Conserved Domains (1) summary
      pfam09750
      Location:573
      DRY_EERY; Alternative splicing regulator
    13. XM_036153244.1XP_036009137.1  CLK4-associating serine/arginine rich protein isoform X8

    14. XM_036153241.1XP_036009134.1  CLK4-associating serine/arginine rich protein isoform X7

    15. XM_006540191.5XP_006540254.1  CLK4-associating serine/arginine rich protein isoform X1

      Conserved Domains (1) summary
      pfam09750
      Location:41169
      DRY_EERY; Alternative splicing regulator
    16. XM_036153243.1XP_036009136.1  CLK4-associating serine/arginine rich protein isoform X7

    17. XM_017322363.1XP_017177852.1  CLK4-associating serine/arginine rich protein isoform X7

    18. XM_036153246.1XP_036009139.1  CLK4-associating serine/arginine rich protein isoform X8

    RNA

    1. XR_004934146.1 RNA Sequence

    2. XR_003946516.1 RNA Sequence

    3. XR_004934145.1 RNA Sequence

    4. XR_003946514.2 RNA Sequence

    5. XR_003946517.2 RNA Sequence

    6. XR_004934148.1 RNA Sequence

    7. XR_004934147.1 RNA Sequence