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    Erlin1 ER lipid raft associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 226144, updated on 23-Jun-2021

    Summary

    Official Symbol
    Erlin1provided by MGI
    Official Full Name
    ER lipid raft associated 1provided by MGI
    Primary source
    MGI:MGI:2387613
    See related
    Ensembl:ENSMUSG00000025198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Keo; Spf; Keo4; Spfh1; C80197; 2810439N09Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 17.3), limb E14.5 (RPKM 8.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Erlin1 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44023382..44058580, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44034943..44070164, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44109433..44144275, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase N, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene predicted gene, 24336

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    erlin-1
    Names
    SPFH domain family, member 1
    SPFH domain-containing protein 1
    endoplasmic reticulum lipid raft-associated protein 1
    protein KE04 homolog
    stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164359.1NP_001157831.1  erlin-1

      See identical proteins and their annotated locations for NP_001157831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC124693, AK145990, BE990958, BM205368, CJ134812
      Consensus CDS
      CCDS29842.2
      UniProtKB/Swiss-Prot
      Q91X78
      UniProtKB/TrEMBL
      A0A0R4J1G5
      Related
      ENSMUSP00000071618.7, ENSMUST00000071698.13
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. NM_001164360.1NP_001157832.1  erlin-1

      See identical proteins and their annotated locations for NP_001157832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK145990, BE990958, BM205368, CJ074662
      Consensus CDS
      CCDS29842.2
      UniProtKB/Swiss-Prot
      Q91X78
      UniProtKB/TrEMBL
      A0A0R4J1G5
      Related
      ENSMUSP00000107659.4, ENSMUST00000112028.10
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. NM_145502.3NP_663477.3  erlin-1

      See identical proteins and their annotated locations for NP_663477.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK133557, BE990958, CN702299
      Consensus CDS
      CCDS29842.2
      UniProtKB/Swiss-Prot
      Q91X78
      UniProtKB/TrEMBL
      A0A0R4J1G5
      Related
      ENSMUSP00000129684.2, ENSMUST00000170801.8
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44023382..44058580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526998.5XP_006527061.1  erlin-1 isoform X1

      See identical proteins and their annotated locations for XP_006527061.1

      UniProtKB/Swiss-Prot
      Q91X78
      UniProtKB/TrEMBL
      A0A0R4J1G5
      Conserved Domains (1) summary
      cd03406
      Location:18310
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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