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    Rbm41 RNA binding motif protein 41 [ Mus musculus (house mouse) ]

    Gene ID: 237073, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rbm41provided by MGI
    Official Full Name
    RNA binding motif protein 41provided by MGI
    Primary source
    MGI:MGI:2444923
    See related
    Ensembl:ENSMUSG00000031433 AllianceGenome:MGI:2444923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D330023I21Rik
    Summary
    Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. Is expressed in brain; cerebral cortex; hippocampus; and retina. Orthologous to human RBM41 (RNA binding motif protein 41). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 2.0), CNS E11.5 (RPKM 1.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F1; X 61.35 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138790260..138899344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139889511..139998595, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene claudin 2 Neighboring gene microrchidia 4 Neighboring gene predicted gene, 52431 Neighboring gene NMD3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_48000 Neighboring gene nucleoporin 62 C-terminal like Neighboring gene dynein axonemal assembly factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47195

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U12 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172147.1 → NP_001165618.1  RNA-binding protein 41 isoform 1

      See identical proteins and their annotated locations for NP_001165618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK164496, AL672270, BC037024, BY125116
      Consensus CDS
      CCDS53204.1
      UniProtKB/Swiss-Prot
      Q8JZV4
      Related
      ENSMUSP00000108631.2, ENSMUST00000113007.8
      Conserved Domains (2) summary
      COG0724
      Location:312 → 403
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:320 → 397
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    2. NM_001172148.1 → NP_001165619.1  RNA-binding protein 41 isoform 3

      See identical proteins and their annotated locations for NP_001165619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, uses an upstream start codon, and has a distinct terminal exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK166005, BY125116
      Consensus CDS
      CCDS53205.1
      UniProtKB/Swiss-Prot
      Q8JZV4
      Related
      ENSMUSP00000084662.6, ENSMUST00000087400.12
      Conserved Domains (2) summary
      COG0724
      Location:300 → 361
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:308 → 362
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001290630.1 → NP_001277559.1  RNA-binding protein 41 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and contains an alternate exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AK084514, AK141075, AL672270, BY125116
      Consensus CDS
      CCDS72439.1
      UniProtKB/TrEMBL
      A2AG09
      Related
      ENSMUSP00000108634.3, ENSMUST00000113011.9
      Conserved Domains (2) summary
      COG0724
      Location:324 → 415
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:332 → 409
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    4. NM_153586.2 → NP_705814.1  RNA-binding protein 41 isoform 2

      See identical proteins and their annotated locations for NP_705814.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL672270, BC037024, BY125116
      Consensus CDS
      CCDS41147.1
      UniProtKB/Swiss-Prot
      A2AG07, Q3TMC8, Q3TPC6, Q8C9Y2, Q8JZV4
      Related
      ENSMUSP00000033810.8, ENSMUST00000033810.8
      Conserved Domains (2) summary
      COG0724
      Location:300 → 391
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12239
      Location:308 → 385
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      138790260..138899344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251329.2 → XP_030107189.1  RNA-binding protein 41 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:339 → 394
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_011247736.4 → XP_011246038.1  RNA-binding protein 41 isoform X1

      Conserved Domains (1) summary
      cd12239
      Location:339 → 416
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    3. XM_030251328.2 → XP_030107188.1  RNA-binding protein 41 isoform X2

      Conserved Domains (1) summary
      cd12239
      Location:315 → 392
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    4. XM_036161932.1 → XP_036017825.1  RNA-binding protein 41 isoform X4

      Conserved Domains (1) summary
      cd12239
      Location:123 → 200
      RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZV4.1 GenPept UniProtKB/Swiss-Prot:Q8JZV4

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