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    Thnsl2 threonine synthase-like 2 (bacterial) [ Mus musculus (house mouse) ]

    Gene ID: 232078, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Thnsl2provided by MGI
    Official Full Name
    threonine synthase-like 2 (bacterial)provided by MGI
    Primary source
    MGI:MGI:3041254
    See related
    Ensembl:ENSMUSG00000054474 AllianceGenome:MGI:3041254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSH2
    Summary
    Enables pyridoxal phosphate binding activity and serine binding activity. Involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Is expressed in renal calyx. Orthologous to human THNSL2 (threonine synthase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 87.1), placenta adult (RPKM 25.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C1; 6 32.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71105150..71121364, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71128166..71144380, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16251 Neighboring gene predicted gene, 38826 Neighboring gene ribosomal protein L34, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71093854-71094037 Neighboring gene STARR-seq mESC enhancer starr_16253 Neighboring gene predicted gene, 30391 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71104939-71105048 Neighboring gene predicted gene, 38827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A threonine synthase homolog from a mammalian genome. Donini S, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17034760
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC59076

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables threonine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxobutyrate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 2-oxobutyrate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serine family amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serine family amino acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within threonine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine synthase-like 2
    NP_001029101.1
    NP_848500.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033929.2 → NP_001029101.1  threonine synthase-like 2

      See identical proteins and their annotated locations for NP_001029101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI156509, AK165463, BQ042728, CX223060
      Consensus CDS
      CCDS20225.1
      UniProtKB/Swiss-Prot
      Q80W22, Q8R135
      Related
      ENSMUSP00000124423.2, ENSMUST00000160918.8
      Conserved Domains (2) summary
      cd01560
      Location:2 → 463
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1 → 453
      PRK09225; threonine synthase; Validated

    2. NM_178413.5 → NP_848500.3  threonine synthase-like 2

      See identical proteins and their annotated locations for NP_848500.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154003, AI156509, AK165463, BQ042728, CX223060
      Consensus CDS
      CCDS20225.1
      UniProtKB/Swiss-Prot
      Q80W22, Q8R135
      Related
      ENSMUSP00000073861.8, ENSMUST00000074241.9
      Conserved Domains (2) summary
      cd01560
      Location:2 → 463
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1 → 453
      PRK09225; threonine synthase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71105150..71121364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W22.1 GenPept UniProtKB/Swiss-Prot:Q80W22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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