U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MRX15 Mrx15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855776, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    MRX15
    Gene description
    Mrx15p
    Primary source
    FungiDB:YNR040W
    Locus tag
    YNR040W
    See related
    SGD:S000005323; AllianceGenome:SGD:S000005323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DPI29
    Summary
    Enables mitochondrial ribosome binding activity. Involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MRX15 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (699690..700460)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative ATP-dependent RNA helicase DBP6 Neighboring gene Zn(2+) transporter ZRG17 Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene diphosphomevalonate decarboxylase MVD1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System. Vargas Möller-Hergt B, et al. Cells, 2018 Oct 17. PMID 30336542, Free PMC Article
    2. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
    4. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article
    5. The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria. Möller-Hergt BV, et al. Mol Biol Cell, 2018 Oct 1. PMID 30091672, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitochondrial ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane from matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mrx15p
    NP_014438.3
    • Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      699690..700460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183217.3 → NP_014438.3  TPA: Mrx15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014438.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1L6, P53736
      UniProtKB/TrEMBL
      A0A8H4BWV7, B3LPK2, B5VR67, C7GLL6, N1NXT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53736.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous