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    ZFAND5 zinc finger AN1-type containing 5 [ Homo sapiens (human) ]

    Gene ID: 7763, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZFAND5provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 5provided by HGNC
    Primary source
    HGNC:HGNC:13008
    See related
    Ensembl:ENSG00000107372 MIM:604761; AllianceGenome:HGNC:13008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZA20D2; ZNF216; ZFAND5A
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 113.8), adrenal (RPKM 84.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q21.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (72351413..72365208, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (84502257..84516065, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (74966329..74980124, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 285 Neighboring gene long intergenic non-protein coding RNA 1504 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:74930554-74931102 Neighboring gene hESC enhancers GRCh37_chr9:74979127-74979830 and GRCh37_chr9:74979831-74980535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28458 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:75069728-75070499 Neighboring gene ribosomal protein S12 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28459 Neighboring gene Sharpr-MPRA regulatory region 9116 Neighboring gene uncharacterized LOC105376080

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity. Mincione G, et al. Oncotarget, 2016 Nov 15. PMID 27732953, Free PMC Article
    2. A RANKL-inducible gene Znf216 in osteoclast differentiation. Hishiya A, et al. J Recept Signal Transduct Res, 2005. PMID 16194934
    3. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Scott DA, et al. Gene, 1998 Jul 30. PMID 9758550
    4. The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions. He G, et al. J Biol Chem, 2012 Jul 20. PMID 22665488, Free PMC Article
    5. Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex. Garner TP, et al. Biochemistry, 2011 Oct 25. PMID 21923101

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results indicate that ZNF216 overexpression sensitizes to apoptosis the NIH3T3/EGFR/ZNF216 cells thus antagonizing the effect of activated EGFR-mediated survival in control cells that do not overexpress the ZNF216.
      Title: Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity.
    2. Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding.
      Title: The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. redundant and distinct roles in regulating NFkappaB activation and apoptosis
      Title: ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
    6. ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway
      Title: A RANKL-inducible gene Znf216 in osteoclast differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in face development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 5
    Names
    zinc finger A20 domain-containing protein 2
    zinc finger protein 216
    zinc finger, A20 domain containing 2
    zinc finger, AN1-type domain 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102420.3 → NP_001095890.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_001095890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript. All six variants encode the same protein.
      Source sequence(s)
      AL135924
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Related
      ENSP00000366161.5, ENST00000376962.10
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    2. NM_001102421.3 → NP_001095891.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_001095891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
      Source sequence(s)
      AL135924
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Related
      ENSP00000366159.4, ENST00000376960.8
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    3. NM_001278243.2 → NP_001265172.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_001265172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
      Source sequence(s)
      AL135924
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Related
      ENSP00000350586.2, ENST00000343431.6
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    4. NM_001278244.1 → NP_001265173.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_001265173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
      Source sequence(s)
      AL135924, BC073131, BX489434, DA290666
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Related
      ENSP00000237937.3, ENST00000237937.7
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    5. NM_001278245.2 → NP_001265174.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_001265174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (f) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
      Source sequence(s)
      AL135924
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    6. NM_006007.4 → NP_005998.1  AN1-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_005998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
      Source sequence(s)
      AL135924
      Consensus CDS
      CCDS6642.1
      UniProtKB/Swiss-Prot
      A8K484, O76080
      Conserved Domains (2) summary
      smart00154
      Location:154 → 191
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      72351413..72365208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423853.1 → XP_047279809.1  AN1-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K484, O76080

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      84502257..84516065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363768.1 → XP_054219743.1  AN1-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K484, O76080
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76080.1 GenPept UniProtKB/Swiss-Prot:O76080

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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