Akap1 A kinase anchor protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap1provided by MGI
Official Full Name: A kinase anchor protein 1provided by MGI
Primary source: MGI:MGI:104729
See related: Ensembl:ENSMUSG00000018428 AllianceGenome:MGI:104729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akap; AKAP84; DAKAP1; AKAP121; S-AKAP84
Summary: Predicted to enable several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in apoptotic process. Located in mitochondrion. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; gut; and olfactory epithelium. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 171.5), heart adult (RPKM 26.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 54.34 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (88721618..88755426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (88830792..88864596, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
Title: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
Title: Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
Title: Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
AKAP121/PKA confers neuroprotection in an in vitro model of oxidative stress induced by exposure to excess glutamate.
Title: Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress.
genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1.
Title: AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
Title: Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
Loss of AKAP1 expression is associated with acute lung injury.
Title: Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.
these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity.
Title: A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.
AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells.
Title: Mitochondrial AKAP1 supports mTOR pathway and tumor growth.
Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Akap1 (e-PCR), detects polymorphism
- UniSTS:479068

RH125987 (e-PCR)
- UniSTS:162699

C81186 (e-PCR)
- UniSTS:160140

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 1, mitochondrial

Names: A kinase (PRKA) anchor protein 1; D-AKAP-1; PRKA1; S-AKAP; a kinase anchor protein 1, mitochondrial; dual specificity A-kinase-anchoring protein 1; protein kinase A-anchoring protein 1; spermatid A-kinase anchor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042541.1 → NP_001036006.1 A-kinase anchor protein 1, mitochondrial

See identical proteins and their annotated locations for NP_001036006.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK020371, AK132749, AL596180, CJ167452

Consensus CDS

CCDS25229.1

UniProtKB/Swiss-Prot

B1AR25, O08714, O08715, P97488

Related

ENSMUSP00000018572.5, ENSMUST00000018572.11

Conserved Domains (3) summary

smart00333
Location:710 → 768

TUDOR; Tudor domain

cd00105
Location:565 → 625

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:658 → 780

TUDOR; Tudor domain
NM_009648.2 → NP_033778.2 A-kinase anchor protein 1, mitochondrial

See identical proteins and their annotated locations for NP_033778.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AK020371, AK132749, AL596180

Consensus CDS

CCDS25229.1

UniProtKB/Swiss-Prot

B1AR25, O08714, O08715, P97488

Related

ENSMUSP00000103536.2, ENSMUST00000107903.8

Conserved Domains (3) summary

smart00333
Location:710 → 768

TUDOR; Tudor domain

cd00105
Location:565 → 625

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:658 → 780

TUDOR; Tudor domain

RNA

NR_104310.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK132749, AK186415, AW985969, BC065135

Related

ENSMUST00000143720.8