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    Ptges3l prostaglandin E synthase 3 like [ Mus musculus (house mouse) ]

    Gene ID: 73635, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ptges3lprovided by MGI
    Official Full Name
    prostaglandin E synthase 3 likeprovided by MGI
    Primary source
    MGI:MGI:1916146
    See related
    Ensembl:ENSMUSG00000097487 AllianceGenome:MGI:1916146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110069E20Rik; 1700113I22Rik
    Summary
    Predicted to enable Hsp90 protein binding activity and chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including AARSD1 (alanyl-tRNA synthetase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 18.5), heart adult (RPKM 9.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptges3l in Genome Data Viewer
    Location:
    11 D; 11 64.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101309634..101316154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101418808..101425947, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30761 Neighboring gene predicted gene, 25475 Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene microRNA 6929 Neighboring gene STARR-positive B cell enhancer ABC_E596 Neighboring gene RUN domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1431 Neighboring gene ribosomal protein L27 Neighboring gene STARR-positive B cell enhancer ABC_E7067 Neighboring gene STARR-seq mESC enhancer starr_30763 Neighboring gene interferon-induced protein 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative protein PTGES3L
    Names
    alanyl-tRNA synthetase domain containing 1
    prostaglandin E synthase 3 (cytosolic)-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357574.1 → NP_001344503.1  putative protein PTGES3L isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK007198, AL732315, AV260990, BY707285
      Consensus CDS
      CCDS88258.1
      UniProtKB/TrEMBL
      A2A4P5
      Related
      ENSMUSP00000102873.3, ENSMUST00000107252.9
      Conserved Domains (1) summary
      cd00237
      Location:5 → 110
      p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

    2. NM_001361123.1 → NP_001348052.1  putative protein PTGES3L isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK007198, AL590996, AV260990, BC057970, BC141198
      UniProtKB/TrEMBL
      B2RUL0
      Conserved Domains (1) summary
      cd00237
      Location:5 → 106
      p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

    3. NM_026865.3 → NP_081141.1  putative protein PTGES3L isoform 2

      See identical proteins and their annotated locations for NP_081141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AL590996, AL732315
      Consensus CDS
      CCDS25468.1
      UniProtKB/Swiss-Prot
      Q9D0U4, Q9D9A7
      Related
      ENSMUSP00000099391.4, ENSMUST00000103102.10
      Conserved Domains (1) summary
      cd00237
      Location:5 → 110
      p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101309634..101316154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534346.4 → XP_006534409.1  putative protein PTGES3L isoform X1

      See identical proteins and their annotated locations for XP_006534409.1

      Conserved Domains (1) summary
      cl00175
      Location:1 → 92
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    RNA

    1. XR_879745.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9A7.1 GenPept UniProtKB/Swiss-Prot:Q9D9A7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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