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    Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 245867, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcmtd2provided by MGI
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1923927
    See related
    Ensembl:ENSMUSG00000027589 AllianceGenome:MGI:1923927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5330414D10Rik
    Summary
    Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in cellular protein modification process. Predicted to be active in cytoplasm. Is expressed in cerebellum and retina outer nuclear layer. Orthologous to human PCMTD2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.1), frontal lobe adult (RPKM 5.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 103.81 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181471952..181499253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181830159..181857460)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene myelin transcription factor 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K Neighboring gene poly(A) binding protein, cytoplasmic 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36470

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-isoaspartate O-methyltransferase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291211.1 → NP_001278140.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL845173, BC031360, BY477720, CD774000, CJ149855
      Consensus CDS
      CCDS71224.1
      UniProtKB/TrEMBL
      B0R0C7, Q6I682
      Related
      ENSMUSP00000104385.2, ENSMUST00000108754.8
      Conserved Domains (3) summary
      pfam01135
      Location:11 → 214
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      pfam12847
      Location:80 → 189
      Methyltransf_18; Methyltransferase domain
      cl17173
      Location:7 → 126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_153594.3 → NP_705822.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_705822.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL845173, BC031360, BY477720, CD774000, CJ149855
      Consensus CDS
      CCDS17224.1
      UniProtKB/Swiss-Prot
      Q3UKB7, Q8BHD8, Q8BJT6, Q8BK38, Q8C0H6, Q8R1D5
      Related
      ENSMUSP00000029116.8, ENSMUST00000029116.14
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181471952..181499253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500620.4 → XP_006500683.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006500683.1

      Conserved Domains (1) summary
      pfam01135
      Location:11 → 214
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    2. XM_006500626.4 → XP_006500689.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      pfam01135
      Location:11 → 220
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    3. XM_006500622.4 → XP_006500685.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam01135
      Location:11 → 220
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    4. XM_006500621.4 → XP_006500684.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006500684.1

      Conserved Domains (1) summary
      pfam01135
      Location:11 → 214
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    5. XM_036162057.1 → XP_036017950.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UKB7, Q8BHD8, Q8BJT6, Q8BK38, Q8C0H6, Q8R1D5
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    6. XM_036162056.1 → XP_036017949.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam01135
      Location:11 → 214
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    RNA

    1. XR_004940357.1 RNA Sequence

    2. XR_004940358.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHD8.1 GenPept UniProtKB/Swiss-Prot:Q8BHD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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