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    Sv2b synaptic vesicle glycoprotein 2b [ Mus musculus (house mouse) ]

    Gene ID: 64176, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sv2bprovided by MGI
    Official Full Name
    synaptic vesicle glycoprotein 2bprovided by MGI
    Primary source
    MGI:MGI:1927338
    See related
    Ensembl:ENSMUSG00000053025 AllianceGenome:MGI:1927338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0735; A830038F04Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within chemical synaptic transmission. Located in synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 34.7), frontal lobe adult (RPKM 26.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sv2b in Genome Data Viewer
    Location:
    7 D1; 7 43.62 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (74764642..74959143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (75114894..75309262, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19211 Neighboring gene predicted gene, 53361 Neighboring gene STARR-seq mESC enhancer starr_19212 Neighboring gene RIKEN cDNA 4930533N22 gene Neighboring gene STARR-seq mESC enhancer starr_19213 Neighboring gene STARR-seq mESC enhancer starr_19214 Neighboring gene STARR-positive B cell enhancer ABC_E11357 Neighboring gene STARR-seq mESC enhancer starr_19215 Neighboring gene RIKEN cDNA 1500012K07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:82463213-82463514 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82507527-82507739 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82515952-82516252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82516993-82517187 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82532718-82533019 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82533022-82533322 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1. Miyamoto M, et al. J Alzheimers Dis, 2020. PMID 32280101
    2. Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Detrait E, et al. Behav Brain Res, 2014 Sep 1. PMID 24937053
    3. SV2 acts via presynaptic calcium to regulate neurotransmitter release. Wan QF, et al. Neuron, 2010 Jun 24. PMID 20620874, Free PMC Article
    4. Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. Morgans CW, et al. PLoS One, 2009. PMID 19381277, Free PMC Article
    5. Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice. Venkatesan K, et al. J Neurosci Res, 2012 Dec. PMID 22847229

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AbetaPP as a Novel Interaction Partner of BACE1.
      Title: Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.
    2. To study the role of SV2B in maintaining the podocyte function and to better understand the function of the neuron-like vesicle expressing SV2B in the podocyte, we analyzed them with SV2B knockout (KO) mice.
      Title: SV2B is essential for the integrity of the glomerular filtration barrier.
    3. Glutamatergic & GABAergic transmission are unaffected by deletion of the SV2B protein. Additional deletion of SV2B does not affect the electrophysiological phenotype of SV2A deletion.
      Title: Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.
    4. Loss of synaptic vesicle glycoprotein 2b is associated with inhibition of tetanus neurotoxin into central neurons.
      Title: SV2 mediates entry of tetanus neurotoxin into central neurons.
    5. These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release.
      Title: SV2 regulates neurotransmitter release via multiple mechanisms.
    6. SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+).
      Title: SV2 acts via presynaptic calcium to regulate neurotransmitter release.
    7. SV2B contributes to the modulation of synaptic vesicle exocytosis and plays a significant role in regulating synaptic protein content
      Title: Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.
    8. Data demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.
      Title: Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
    9. SV2B-synaptotagmin 1 complex is involved in the regulation of synaptotagmin 1 stability and/or trafficking
      Title: SV2B regulates synaptotagmin 1 by direct interaction.
    10. findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
      Title: SV2 is the protein receptor for botulinum neurotoxin A.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38746

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptic vesicle glycoprotein 2B
    Names
    synaptic vesicle glycoprotein 2 b
    synaptic vesicle protein 2B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109753.1 → NP_001103223.1  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_001103223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AK043830, AK147261, BC060224, BY269935
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000082254.6, ENSMUST00000085164.7
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    2. NM_001360571.1 → NP_001347500.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    3. NM_001360572.1 → NP_001347501.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    4. NM_001360573.1 → NP_001347502.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    5. NM_001360574.1 → NP_001347503.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    6. NM_001360575.1 → NP_001347504.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC116898, AK029736, BC060224
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000146049.2, ENSMUST00000206344.2
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    7. NM_153579.4 → NP_705807.2  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_705807.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      BC060224, BC079568
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000127245.2, ENSMUST00000165175.8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      74764642..74959143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153323.1 → XP_036009216.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    2. XM_036153324.1 → XP_036009217.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    3. XM_006541059.4 → XP_006541122.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_006541122.1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG39.1 GenPept UniProtKB/Swiss-Prot:Q8BG39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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