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    Sf1 splicing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 22668, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sf1provided by MGI
    Official Full Name
    splicing factor 1provided by MGI
    Primary source
    MGI:MGI:1095403
    See related
    Ensembl:ENSMUSG00000024949 AllianceGenome:MGI:1095403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BBP; MZFM; WBP4; Zfp162
    Summary
    Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: SF1 (Gene ID: 22668) and NR5A1 (Gene ID: 26423) share the SF1 symbol/alias in common. SF1 is a widely used alternative name for nuclear receptor subfamily 5 group A member 1 (NR5A1), which can be confused with the official symbol for SF1 (splicing factor 1). [30 Mar 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 49.7), adrenal adult (RPKM 41.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6413952..6428060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6363673..6378038)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene predicted gene, 57665 Neighboring gene muscle glycogen phosphorylase Neighboring gene STARR-positive B cell enhancer ABC_E4263 Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Shitashige M, et al. Cancer Sci, 2007 Dec. PMID 17900258
    2. Genomic organization of mouse gene zfp162. Wrehlke C, et al. DNA Cell Biol, 1999 May. PMID 10360842
    3. Enhanced expression in spleen macrophages of the mouse homolog to the human putative tumor suppressor gene ZFM1. Wrehlke C, et al. DNA Cell Biol, 1997 Jun. PMID 9212169
    4. Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors. Qin F, et al. Reprod Biomed Online, 2015 Nov. PMID 26386639
    5. SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells. Kulcenty K, et al. Mol Cell Biochem, 2015 Oct. PMID 26122391, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sf1 SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone)
      Title: Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
    2. we found that KLF6 transcriptionally cooperates with NUR77 and SF1
      Title: KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.
    3. the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression.
      Title: Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.
    4. Results clearly indicate that SF-1 is involved in the regulation of LIPE expression after activation of protein kinase A in adrenocortical cells.
      Title: SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells.
    5. SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development.
      Title: Involvement of SF-1 in neurogenesis and neuronal migration in the developing neocortex.
    6. SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
      Title: SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
    7. Data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis.
      Title: Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.
    8. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis indicates the involvement of SF1 in the beta-catenin-mediated regulation of proliferation.
      Title: Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Leydig cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within male sex determination IGI
    Inferred from Genetic Interaction
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of steroid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    part_of U2AF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 1
    Names
    mammalian branch point-binding protein
    transcription factor ZFM1
    zinc finger gene in MEN1 locus
    zinc finger protein 162

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110791.2 → NP_001104261.1  splicing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001104261.1

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      Consensus CDS
      CCDS50368.1
      UniProtKB/TrEMBL
      Q3UI45, Q3UK67
      Related
      ENSMUSP00000121309.2, ENSMUST00000131252.8
      Conserved Domains (2) summary
      smart00343
      Location:278 → 293
      ZnF_C2HC; zinc finger
      COG5176
      Location:17 → 257
      MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

    2. NM_001360393.2 → NP_001347322.1  splicing factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      Conserved Domains (1) summary
      cl25681
      Location:29 → 211
      SF1-HH; Splicing factor 1 helix-hairpin domain

    3. NM_001403434.1 → NP_001390363.1  splicing factor 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    4. NM_001403435.1 → NP_001390364.1  splicing factor 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    5. NM_001403436.1 → NP_001390365.1  splicing factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    6. NM_001403439.1 → NP_001390368.1  splicing factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    7. NM_001403440.1 → NP_001390369.1  splicing factor 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      UniProtKB/TrEMBL
      D3YZC9
      Related
      ENSMUSP00000109117.2, ENSMUST00000113489.8

    8. NM_001403441.1 → NP_001390370.1  splicing factor 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    9. NM_001403442.1 → NP_001390371.1  splicing factor 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    10. NM_001403443.1 → NP_001390372.1  splicing factor 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    11. NM_001403444.1 → NP_001390373.1  splicing factor 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    12. NM_001403445.1 → NP_001390374.1  splicing factor 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      Conserved Domains (2) summary
      smart00343
      Location:278 → 293
      ZnF_C2HC; zinc finger
      COG5176
      Location:17 → 257
      MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

    13. NM_001403446.1 → NP_001390375.1  splicing factor 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    14. NM_001403447.1 → NP_001390376.1  splicing factor 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    15. NM_001403448.1 → NP_001390377.1  splicing factor 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245

    16. NM_001403449.1 → NP_001390378.1  splicing factor 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      UniProtKB/TrEMBL
      D3YZD0
      Related
      ENSMUSP00000109116.2, ENSMUST00000113488.8

    17. NM_011750.3 → NP_035880.2  splicing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_035880.2

      Status: VALIDATED

      Source sequence(s)
      AC127556, AC167245
      Consensus CDS
      CCDS50369.1
      UniProtKB/TrEMBL
      E9Q4Q2, Q3TZI3
      Related
      ENSMUSP00000109115.2, ENSMUST00000113487.8
      Conserved Domains (2) summary
      smart00343
      Location:278 → 293
      ZnF_C2HC; zinc finger
      COG5176
      Location:17 → 257
      MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6413952..6428060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_122118.1: Suppressed sequence

      Description
      NR_122118.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64213.6 GenPept UniProtKB/Swiss-Prot:Q64213

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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