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    Plpp2 phospholipid phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 50784, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plpp2provided by MGI
    Official Full Name
    phospholipid phosphatase 2provided by MGI
    Primary source
    MGI:MGI:1354945
    See related
    Ensembl:ENSMUSG00000052151 AllianceGenome:MGI:1354945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lpp2; PAP2c; PAP2-G; Ppap2c; PAP2-gamma
    Summary
    The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Broad expression in large intestine adult (RPKM 123.4), small intestine adult (RPKM 120.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79362258..79369621, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79526424..79533787, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 82 Neighboring gene STARR-seq mESC enhancer starr_27245 Neighboring gene vomeronasal 2, receptor 83 Neighboring gene STARR-seq mESC enhancer starr_27246 Neighboring gene STARR-seq mESC enhancer starr_27247 Neighboring gene microRNA 6909 Neighboring gene MIER family member 2 Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Zhang N, et al. Genesis, 2000 Aug. PMID 10992322
    2. Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases. Zhang N, et al. Genomics, 2000 Jan 1. PMID 10662554
    3. The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Escalante-Alcalde D, et al. Development, 2003 Oct. PMID 12925589
    4. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
    5. The in vivo brain interactome of the amyloid precursor protein. Bai Y, et al. Mol Cell Proteomics, 2008 Jan. PMID 17934213

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sphingosine-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase 2
    Names
    lipid phosphate phosphohydrolase 2
    phosphatidate phosphohydrolase type 2c
    phosphatidic acid phosphatase 2c
    phosphatidic acid phosphatase type 2C
    NP_001289318.1
    NP_001289319.1
    NP_001289371.1
    NP_056632.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302389.1 → NP_001289318.1  phospholipid phosphatase 2 isoform 2

      See identical proteins and their annotated locations for NP_001289318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AK005452, AK049581, BB737982, BB868752, CA540403
      Consensus CDS
      CCDS78849.1
      UniProtKB/TrEMBL
      G3XA61
      Related
      ENSMUST00000163602.9
      Conserved Domains (1) summary
      cd03384
      Location:38 → 183
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_001302390.1 → NP_001289319.1  phospholipid phosphatase 2 isoform 3

      See identical proteins and their annotated locations for NP_001289319.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC100708, AK005452, AK049581, BB737982, BB868752, BQ571983
      Consensus CDS
      CCDS88047.1
      UniProtKB/TrEMBL
      A0A1W2P7I9
      Related
      ENSMUSP00000151683.2, ENSMUST00000218241.2
      Conserved Domains (1) summary
      cd03384
      Location:1 → 121
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    3. NM_001302442.1 → NP_001289371.1  phospholipid phosphatase 2 isoform 2

      See identical proteins and their annotated locations for NP_001289371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AK049581, BB737982, BB868752
      Consensus CDS
      CCDS78849.1
      UniProtKB/TrEMBL
      G3XA61
      Related
      ENSMUSP00000133247.2, ENSMUST00000166804.2
      Conserved Domains (1) summary
      cd03384
      Location:38 → 183
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    4. NM_015817.3 → NP_056632.2  phospholipid phosphatase 2 isoform 1

      See identical proteins and their annotated locations for NP_056632.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK049581, BB737982, BB868752
      Consensus CDS
      CCDS35966.1
      UniProtKB/Swiss-Prot
      Q9DAX2, Q9WUA4
      UniProtKB/TrEMBL
      Q5U4G4
      Related
      ENSMUSP00000069670.6, ENSMUST00000063879.13
      Conserved Domains (1) summary
      cd03384
      Location:94 → 239
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79362258..79369621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAX2.1 GenPept UniProtKB/Swiss-Prot:Q9DAX2

    Gene LinkOut

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