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    Mier2 MIER family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 70427, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mier2provided by MGI
    Official Full Name
    MIER family member 2provided by MGI
    Primary source
    MGI:MGI:1917677
    See related
    Ensembl:ENSMUSG00000042570 AllianceGenome:MGI:1917677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mi-er2; mKIAA1193; 2700087H15Rik
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human MIER2 (MIER family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 17.7), adrenal adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79376079..79395229, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79540245..79557042, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 83 Neighboring gene STARR-seq mESC enhancer starr_27246 Neighboring gene STARR-seq mESC enhancer starr_27247 Neighboring gene phospholipid phosphatase 2 Neighboring gene microRNA 6909 Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808 Neighboring gene C2 calcium-dependent domain containing 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
    2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm induction early response protein 2
    Names
    mesoderm induction early response 1, family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316699.2 → NP_001303628.1  mesoderm induction early response protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC100708
      Consensus CDS
      CCDS83723.1
      UniProtKB/Swiss-Prot
      Q3U3N0, Q5XJI0, Q66JU5, Q69ZP0, Q6NXL7
      Related
      ENSMUSP00000127387.2, ENSMUST00000165028.8
      Conserved Domains (3) summary
      smart00717
      Location:300 → 346
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:301 → 345
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:196 → 246
      ELM2; ELM2 domain

    2. NM_027422.4 → NP_081698.2  mesoderm induction early response protein 2 isoform 2

      See identical proteins and their annotated locations for NP_081698.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
      Source sequence(s)
      AC100708
      Consensus CDS
      CCDS48619.1
      UniProtKB/Swiss-Prot
      Q3U3N0
      Related
      ENSMUSP00000059864.9, ENSMUST00000062855.15
      Conserved Domains (3) summary
      smart00717
      Location:298 → 344
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:299 → 343
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:194 → 244
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79376079..79395229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514083.4 → XP_006514146.1  mesoderm induction early response protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006514146.1

      Conserved Domains (2) summary
      cd11661
      Location:301 → 345
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:196 → 246
      ELM2; ELM2 domain

    2. XM_036155999.1 → XP_036011892.1  mesoderm induction early response protein 2 isoform X7

      Conserved Domains (2) summary
      cd11661
      Location:105 → 149
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:1 → 50
      ELM2; ELM2 domain

    3. XM_036155995.1 → XP_036011888.1  mesoderm induction early response protein 2 isoform X5

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    4. XM_006514086.1 → XP_006514149.1  mesoderm induction early response protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006514149.1

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    5. XM_036156000.1 → XP_036011893.1  mesoderm induction early response protein 2 isoform X7

      Conserved Domains (2) summary
      cd11661
      Location:105 → 149
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:1 → 50
      ELM2; ELM2 domain

    6. XM_006514082.2 → XP_006514145.1  mesoderm induction early response protein 2 isoform X2

      Conserved Domains (2) summary
      cd11661
      Location:314 → 358
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:209 → 259
      ELM2; ELM2 domain

    7. XM_006514081.1 → XP_006514144.1  mesoderm induction early response protein 2 isoform X1

      Conserved Domains (2) summary
      cd11661
      Location:314 → 358
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:209 → 259
      ELM2; ELM2 domain

    8. XM_036155997.1 → XP_036011890.1  mesoderm induction early response protein 2 isoform X7

      Conserved Domains (2) summary
      cd11661
      Location:105 → 149
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:1 → 50
      ELM2; ELM2 domain

    9. XM_036155996.1 → XP_036011889.1  mesoderm induction early response protein 2 isoform X6

      Conserved Domains (2) summary
      cd11661
      Location:105 → 149
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:1 → 50
      ELM2; ELM2 domain

    10. XM_030245264.2 → XP_030101124.1  mesoderm induction early response protein 2 isoform X5

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    11. XM_017314086.3 → XP_017169575.1  mesoderm induction early response protein 2 isoform X4

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    12. XM_030245265.2 → XP_030101125.1  mesoderm induction early response protein 2 isoform X5

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    13. XM_006514085.2 → XP_006514148.1  mesoderm induction early response protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006514148.1

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    14. XM_030245263.1 → XP_030101123.1  mesoderm induction early response protein 2 isoform X4

      Conserved Domains (2) summary
      cd11661
      Location:265 → 309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160 → 210
      ELM2; ELM2 domain

    15. XM_036155998.1 → XP_036011891.1  mesoderm induction early response protein 2 isoform X7

      Conserved Domains (2) summary
      cd11661
      Location:105 → 149
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:1 → 50
      ELM2; ELM2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3N0.1 GenPept UniProtKB/Swiss-Prot:Q3U3N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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