Cnn1 calponin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnn1provided by MGI
Official Full Name: calponin 1provided by MGI
Primary source: MGI:MGI:104979
See related: Ensembl:ENSMUSG00000001349 AllianceGenome:MGI:104979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CN; CnnI
Summary: Predicted to enable actin binding activity. Predicted to be involved in negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be active in cytoskeleton. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system gland; and lung. Orthologous to human CNN1 (calponin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 1016.2), colon adult (RPKM 481.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 8.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (22010501..22020517)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (22099221..22109221)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.
Title: Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.
Cnn1(-/-) and Cnn2(-/-) double knockout aortic smooth muscle exhibits faster relaxation than that of wild type control.
Title: Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle.
Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
Title: Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
These findings reveal a novel function of CNN1 in maintaining bone homeostasis by coupling bone formation to bone resorption
Title: Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation.
data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility.
Title: Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor.
A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation.
Title: Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.
The structure of this functionally important region of calponin and its interaction with actin and calmodulin at amino-acid resolution, was mapped.
Title: The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy.
Mutated mice showed increased locomotor activity, as well as increased intake of food and water, associated with the decreased number of neurons in the paraventricular nucleus of the hypothalamus (PVN)
Title: Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice.
Up-regulation of h1-calponin in SM-B null mice may be necessary to maintain reduced level of cross-bridge cycling over time in absence of SM-B myosin and play important role in regulating smooth muscle contraction.
Title: Effects of h1-calponin ablation on the contractile properties of bladder versus vascular smooth muscle in mice lacking SM-B myosin.
CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility
Title: Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131049 (e-PCR)
- UniSTS:214332

Cnn1 (e-PCR), detects polymorphism
- UniSTS:516205

PMC209322P3 (e-PCR)
- UniSTS:271987

Z19542 (e-PCR)
- UniSTS:125918

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: calponin-1

Names: basic calponin; calponin H1, smooth muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009922.4 → NP_034052.3 calponin-1

See identical proteins and their annotated locations for NP_034052.3

Status: VALIDATED

Source sequence(s)

AK035548, BY326336

Consensus CDS

CCDS22921.1

UniProtKB/Swiss-Prot

Q08091

UniProtKB/TrEMBL

B2RSH3, Q8CBQ2

Related

ENSMUSP00000001384.5, ENSMUST00000001384.6

Conserved Domains (3) summary

COG5199
Location:18 → 188

SCP1; Calponin [Cytoskeleton]

pfam00307
Location:29 → 127

CH; Calponin homology (CH) domain

pfam00402
Location:164 → 187

Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

22010501..22020517

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242388.3 → XP_011240690.2 calponin-1 isoform X1

UniProtKB/TrEMBL

Q8CBQ2

Conserved Domains (2) summary

pfam00402
Location:213 → 237

Calponin; Calponin family repeat

cd21282
Location:76 → 183

CH_CNN1; calponin homology (CH) domain found in calponin-1 and similar proteins
XM_006509969.3 → XP_006510032.1 calponin-1 isoform X2

See identical proteins and their annotated locations for XP_006510032.1

UniProtKB/TrEMBL

A0A1L1SUB2

Related

ENSMUSP00000150665.2, ENSMUST00000216872.2

Conserved Domains (2) summary

COG5199
Location:1 → 138

SCP1; Calponin [Cytoskeleton]

pfam00402
Location:154 → 177

Calponin; Calponin family repeat