Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srxn1provided by MGI
Official Full Name: sulfiredoxin 1 homolog (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:104971
See related: Ensembl:ENSMUSG00000032802 AllianceGenome:MGI:104971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srx; Npn3; Srx1; TX01; 1700127B04Rik
Summary: Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adrenal medulla and embryo. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 100.0), adrenal adult (RPKM 95.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (151946738..151953296)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152105524..152111376)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
Title: DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
These results demonstrated that Srxn1 protects podocytes from high glucose-induced injury by promoting the activation of Nrf2/ARE signaling associated with inactivating GSK-3beta, indicating a potential role of Srxn1 in diabetic nephropathy.
Title: Sulfiredoxin-1 alleviates high glucose-induced podocyte injury though promoting Nrf2/ARE signaling via inactivation of GSK-3β.
essential for normal responses to GnRH stimulation and plays an important role in reactive oxygen species management
Title: SRXN1 Is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression.
sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state.
Title: Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Srx is one of the critical components that contribute to mouse skin tumorigenesis in vivo.
Title: Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.
data provide in vivo evidence that loss of Srx renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis, suggesting that Srx has a critical oncogenic role in cancer development
Title: Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria.
Title: Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.
Srx functions as a novel component to maintain the balance between H2O2 production and elimination
Title: Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2.
NO-mediated Srx up-regulation is mediated by the transcription factor nuclear factor erythroid 2-related factor (Nrf2) and the NO/Srx pathway inhibits generation of reactive oxygen species.
Title: Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages.
Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock
Title: Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI854065 (e-PCR)
- UniSTS:165220

Srxn1 (e-PCR), detects polymorphism
- UniSTS:525998

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on a sulfur group of donors	ISO Inferred from Sequence Orthology more info
enables sulfiredoxin activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sulfiredoxin-1

Names: neoplastic progression 3; neoplastic progression protein 3

NP_083964.2

EC 1.8.98.2

XP_036018567.1

EC 1.8.98.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029688.5 → NP_083964.2 sulfiredoxin-1

Status: VALIDATED

Source sequence(s)

AI851151, AL845161, BC049957

Consensus CDS

CCDS16877.2

UniProtKB/Swiss-Prot

Q3TWN6, Q91VN5, Q9D975

UniProtKB/TrEMBL

A2AQU8

Related

ENSMUSP00000046196.8, ENSMUST00000041500.8

Conserved Domains (1) summary

cd16395
Location:59 → 148

Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

151946738..151953296

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162674.1 → XP_036018567.1 sulfiredoxin-1 isoform X1

UniProtKB/Swiss-Prot

Q3TWN6, Q91VN5, Q9D975

UniProtKB/TrEMBL

A2AQU8

Conserved Domains (1) summary

cd16395
Location:59 → 148

Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation