Chn2 chimerin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chn2provided by MGI
Official Full Name: chimerin 2provided by MGI
Primary source: MGI:MGI:1917243
See related: Ensembl:ENSMUSG00000004633 AllianceGenome:MGI:1917243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bch; ARHGAP3; 1700026N20Rik; 4930557O16Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 91.1), testis adult (RPKM 53.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 26.54 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (54016917..54278797)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (54039932..54301812)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

essential for neural stem cell homeostasis in mouse adult neurogenesis
Title: α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis.
our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.
Title: A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Study demonstrates that Sema3F-dependent inhibition of Rac1 by the Rac-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
Title: The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
Title: A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488811

MARC_10419-10420:999636317:1 (e-PCR)
- UniSTS:267136

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-chimaerin

Names: Rho GTPase-activating protein 3; chimerin (chimaerin) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163640.1 → NP_001157112.1 beta-chimaerin isoform 2

See identical proteins and their annotated locations for NP_001157112.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate, upstream transcription initiation site, uses a distinct start codon and contains several additional exons, compared to variant 1. The resulting protein (isoform 2, also referred to as beta2-chimerin) has a much longer and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK131641, BB617538, BB676245, BM935649, BQ175659

Consensus CDS

CCDS51778.1

UniProtKB/TrEMBL

Q3V2R3

Related

ENSMUSP00000035908.8, ENSMUST00000046856.14

Conserved Domains (3) summary

cd10352
Location:52 → 138

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:275 → 468

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:215 → 267

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001311133.1 → NP_001298062.1 beta-chimaerin isoform 3

See identical proteins and their annotated locations for NP_001298062.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC084220, AI848376, AK006398, AK131641

Consensus CDS

CCDS80535.1

UniProtKB/TrEMBL

B9EIU7

Related

ENSMUSP00000114476.2, ENSMUST00000146114.8

Conserved Domains (2) summary

cd04372
Location:89 → 282

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:24 → 84

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
NM_001311134.1 → NP_001298063.1 beta-chimaerin isoform 4

See identical proteins and their annotated locations for NP_001298063.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC084220, AI848376, AK006398, BU583546

Consensus CDS

CCDS80536.1

UniProtKB/TrEMBL

B9EIU7, Q3TVA5

Related

ENSMUSP00000110043.2, ENSMUST00000114401.8

Conserved Domains (2) summary

cd04372
Location:84 → 277

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:19 → 79

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
NM_023543.2 → NP_076032.2 beta-chimaerin isoform 1

See identical proteins and their annotated locations for NP_076032.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AK131641, BB676245, BM935649, BQ175659, CX238009

Consensus CDS

CCDS20154.1

UniProtKB/Swiss-Prot

Q80XD1, Q9D9W2, Q9ER57

UniProtKB/TrEMBL

B9EIU7

Related

ENSMUSP00000066078.8, ENSMUST00000067741.10

Conserved Domains (2) summary

cd04372
Location:139 → 332

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:79 → 131

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

54016917..54278797

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152294.1 → XP_036008187.1 beta-chimaerin isoform X1

UniProtKB/TrEMBL

B9EIU7

Conserved Domains (2) summary

cd04372
Location:129 → 322

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:64 → 124

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
XM_030255589.2 → XP_030111449.1 beta-chimaerin isoform X3

Conserved Domains (2) summary

cd04372
Location:41 → 234

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:1 → 36

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_006506578.4 → XP_006506641.1 beta-chimaerin isoform X2

See identical proteins and their annotated locations for XP_006506641.1

UniProtKB/TrEMBL

B9EIU7, Q3TVA5

Related

ENSMUSP00000110044.3, ENSMUST00000114402.9

Conserved Domains (2) summary

cd04372
Location:84 → 277

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:19 → 79

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins