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    Rras related RAS viral (r-ras) oncogene [ Mus musculus (house mouse) ]

    Gene ID: 20130, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rrasprovided by MGI
    Official Full Name
    related RAS viral (r-ras) oncogeneprovided by MGI
    Primary source
    MGI:MGI:98179
    See related
    Ensembl:ENSMUSG00000038387 AllianceGenome:MGI:98179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rras1
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 109.9), bladder adult (RPKM 109.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44665686..44671070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45017942..45021646)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E130 Neighboring gene microRNA 7054 Neighboring gene STARR-positive B cell enhancer ABC_E871 Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Vähätupa M, et al. Int J Mol Sci, 2023 Apr 26. PMID 37175621, Free PMC Article
    2. R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development. Herrera JL, et al. J Vasc Res, 2021. PMID 33873190, Free PMC Article
    3. R-Ras regulates vascular permeability, but not overall healing in skin wounds. Ketomäki T, et al. Exp Dermatol, 2019 Feb. PMID 30489650
    4. R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature. Li F, et al. Nat Commun, 2017 Nov 23. PMID 29170374, Free PMC Article
    5. R-Ras deficiency does not affect papain-induced IgE production in mice. Kummola L, et al. Immun Inflamm Dis, 2017 Sep. PMID 28497586, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
      Title: Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
    2. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
      Title: R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
    3. R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
      Title: R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
    4. Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
      Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
    5. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
      Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
    6. although R-Ras does not influence the skin wound healing itself, the blood vessels lacking R-Ras are leaky and thus could facilitate the access of blood-derived proteins to the wound
      Title: R-Ras regulates vascular permeability, but not overall healing in skin wounds.
    7. FliI is required for the interaction of Rasgap(120) with G3BP1 to regulate R-ras activity and growth of cell extensions.
      Title: The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.
    8. Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice.
      Title: R-Ras deficiency does not affect papain-induced IgE production in mice.
    9. R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment.
      Title: Resistance of R-Ras knockout mice to skin tumour induction.
    10. the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules.
      Title: R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129444, MGC129445

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of Schwann cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Schwann cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein R-Ras
    Names
    Harvey rat sarcoma oncogene, subgroup R
    p23
    NP_001347061.1
    NP_001347062.1
    NP_033127.1
    XP_036008706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360132.2 → NP_001347061.1  ras-related protein R-Ras isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC126256
      Conserved Domains (1) summary
      cl21455
      Location:2 → 141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001360133.2 → NP_001347062.1  ras-related protein R-Ras isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC126256
      Conserved Domains (1) summary
      cl21455
      Location:1 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_009101.4 → NP_033127.1  ras-related protein R-Ras isoform 1

      See identical proteins and their annotated locations for NP_033127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC126256
      Consensus CDS
      CCDS21226.1
      UniProtKB/Swiss-Prot
      P10833
      UniProtKB/TrEMBL
      Q3U1N3
      Related
      ENSMUSP00000042150.8, ENSMUST00000044111.10
      Conserved Domains (1) summary
      cd04145
      Location:28 → 191
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44665686..44671070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152813.1 → XP_036008706.1  ras-related protein R-Ras isoform X1

      UniProtKB/Swiss-Prot
      P10833
      UniProtKB/TrEMBL
      Q3U1N3
      Conserved Domains (1) summary
      cd04145
      Location:28 → 191
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10833.1 GenPept UniProtKB/Swiss-Prot:P10833

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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