Cxcl14 C-X-C motif chemokine ligand 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcl14provided by MGI
Official Full Name: C-X-C motif chemokine ligand 14provided by MGI
Primary source: MGI:MGI:1888514
See related: Ensembl:ENSMUSG00000021508 AllianceGenome:MGI:1888514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik
Summary: Predicted to enable chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Acts upstream of or within inner ear development; negative regulation of myoblast differentiation; and positive regulation of natural killer cell chemotaxis. Predicted to be located in Golgi apparatus. Is expressed in several structures, including eye; genitourinary system; limb; trophectoderm; and vibrissa. Orthologous to human CXCL14 (C-X-C motif chemokine ligand 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 108.6), bladder adult (RPKM 100.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (56436456..56444624, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (56288643..56296811, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis.
Title: CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis.
Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter Methylation.
Title: Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter Methylation.
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option.
Title: Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option.
IRX1 ameliorates sepsis-induced acute kidney injury in mice by promoting CXCL14.
Title: IRX1 ameliorates sepsis-induced acute kidney injury in mice by promoting CXCL14.
CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages.
Title: CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages.
CXCL14 Attenuates Triple-Negative Breast Cancer Progression by Regulating Immune Profiles of the Tumor Microenvironment in a T Cell-Dependent Manner.
Title: CXCL14 Attenuates Triple-Negative Breast Cancer Progression by Regulating Immune Profiles of the Tumor Microenvironment in a T Cell-Dependent Manner.
Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity.
Title: Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity.
Exosomal CXCL14 Contributes to M2 Macrophage Polarization through NF-kappaB Signaling in Prostate Cancer.
Title: Exosomal CXCL14 Contributes to M2 Macrophage Polarization through NF-κB Signaling in Prostate Cancer.
The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4.
Title: The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4.
Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA.
Title: Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

AI414372 (e-PCR)
- UniSTS:160311

Cxcl14 (e-PCR), detects polymorphism
- UniSTS:527057

NoName (e-PCR)
- UniSTS:237033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in killing of cells of another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 14

Names: B-cell and monocyte-activating chemokine; chemokine (C-X-C motif) ligand 14; chemokine BRAK; kidney-expressed chemokine CXC; musculus CXC chemokine MIP-2gamma; small inducible cytokine subfamily B (Cys-X-Cys), member 14; small-inducible cytokine B14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019568.2 → NP_062514.2 C-X-C motif chemokine 14 precursor

See identical proteins and their annotated locations for NP_062514.2

Status: VALIDATED

Source sequence(s)

AK076112, AU035952, BC079661, BI133967

Consensus CDS

CCDS36679.1

UniProtKB/Swiss-Prot

Q548T5, Q91V02, Q9JHH7, Q9WUQ5

Related

ENSMUSP00000021970.10, ENSMUST00000021970.11

Conserved Domains (1) summary

cl00134
Location:24 → 85

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

56436456..56444624 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244545.3 → XP_011242847.1 C-X-C motif chemokine 14 isoform X1

See identical proteins and their annotated locations for XP_011242847.1

Conserved Domains (1) summary

cl00134
Location:24 → 85

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
XM_006517307.5 → XP_006517370.1 C-X-C motif chemokine 14 isoform X1

See identical proteins and their annotated locations for XP_006517370.1

Conserved Domains (1) summary

cl00134
Location:24 → 85

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
XM_006517308.5 → XP_006517371.1 C-X-C motif chemokine 14 isoform X2

See identical proteins and their annotated locations for XP_006517371.1

UniProtKB/Swiss-Prot

Q548T5, Q91V02, Q9JHH7, Q9WUQ5

Conserved Domains (1) summary

cl00134
Location:24 → 85

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...