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    Apcdd1 adenomatosis polyposis coli down-regulated 1 [ Mus musculus (house mouse) ]

    Gene ID: 494504, updated on 7-May-2024

    Summary

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    Official Symbol
    Apcdd1provided by MGI
    Official Full Name
    adenomatosis polyposis coli down-regulated 1provided by MGI
    Primary source
    MGI:MGI:3513977
    See related
    Ensembl:ENSMUSG00000071847 AllianceGenome:MGI:3513977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drapc1; EIG180
    Summary
    Predicted to enable Wnt-protein binding activity and identical protein binding activity. Involved in regulation of odontogenesis of dentin-containing tooth. Acts upstream of or within astrocyte cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; ear; and reproductive system. Human ortholog(s) of this gene implicated in hypotrichosis 1. Orthologous to human APCDD1 (APC down-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 94.0), limb E14.5 (RPKM 52.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apcdd1 in Genome Data Viewer
    Location:
    18 E1; 18 35.95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63055398..63086886)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62922327..62953815)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598 Neighboring gene STARR-seq mESC enhancer starr_44779 Neighboring gene STARR-seq mESC enhancer starr_44780 Neighboring gene predicted gene, 41752 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene predicted gene, 36651

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Mazzoni J, et al. Neuron, 2017 Dec 6. PMID 29154126, Free PMC Article
    2. Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation. Biswas S, et al. Development, 2022 Sep 1. PMID 36098369, Free PMC Article
    3. A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity. Yiew NKH, et al. J Biol Chem, 2017 Apr 14. PMID 28242765, Free PMC Article
    4. The role of APCDD1 in epithelial rearrangement in tooth morphogenesis. Neupane S, et al. Histochem Cell Biol, 2015 Oct. PMID 26170146
    5. Transposition-based method for the rapid generation of gene-targeting vectors to produce Cre/Flp-modifiable conditional knock-out mice. Turakainen H, et al. PLoS One, 2009. PMID 19194496, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these novel findings suggest that APCDD1 positively regulates adipogenic differentiation and that its down-regulation by miR-130 during diet-induced obesity may contribute to impaired adipogenic differentiation and obesity-related metabolic disease.
      Title: A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
    2. Suggest that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating epithelial rearrangement.
      Title: The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.
    3. mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway
      Title: Drapc1 expression during mouse embryonic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within astrocyte cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein APCDD1
    Names
    adenomatosis polyposis coli down-regulated 1 protein homolog
    ethanol induced gene product EIG180

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133237.4 → NP_573500.2  protein APCDD1 precursor

      See identical proteins and their annotated locations for NP_573500.2

      Status: VALIDATED

      Source sequence(s)
      AC130204
      Consensus CDS
      CCDS37843.1
      UniProtKB/Swiss-Prot
      B2RUN4, Q3TA99, Q3U128
      Related
      ENSMUSP00000157539.2, ENSMUST00000236135.2
      Conserved Domains (1) summary
      pfam14921
      Location:51 → 282
      APCDDC; Adenomatosis polyposis coli down-regulated 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      63055398..63086886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161200.1 → XP_036017093.1  protein APCDD1 isoform X1

      Conserved Domains (1) summary
      pfam14921
      Location:1 → 192
      APCDDC; Adenomatosis polyposis coli down-regulated 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U128.1 GenPept UniProtKB/Swiss-Prot:Q3U128

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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