Npy5r neuropeptide Y receptor Y5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npy5rprovided by MGI
Official Full Name: neuropeptide Y receptor Y5provided by MGI
Primary source: MGI:MGI:108082
See related: Ensembl:ENSMUSG00000044014 AllianceGenome:MGI:108082
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Y5R; NPY5-R; NPYY5-R
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 1.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 33.15 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (67132617..67140746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (66679965..66688094, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
Title: Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
Study suggests that PYY3-36 mediated signalling via Y5 receptors may counteract the anorectic effects that it mediates via the Y2 receptor, consequently lowering bodyweight in the absence of Y5 signalling.
Title: Y5 receptor signalling counteracts the anorectic effects of PYY3-36 in diet-induced obese mice.
NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Title: Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
Y5-immunoreactivity was distributed widely in mouse brain, and the Y5 protein localization was mostly observed in the somata of the Y5 neurons. By purifying the polyclonal antibody with fixed knockout mouse tissue, the precise Y5 localization became obvious in mouse brain, especially in areas other than the hypothalamic area.
Title: Neuropeptide Y Y(5) receptor localization in mouse central nervous system.
Npy1r(Y5R-/-) mice show increased anxiety-related behavior but no changes in hypothalamus-pituitary-adrenocortical axis activity or in body weight growth, independently of gender and mouse strain used as foster mothers. Also, Npy1r(Y5R-/-) mice of both genders display increased spatial reference memory in the Morris water maze test.
Title: Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety.
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
Title: Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.
Y5 KO mice display increased grooming and rearing in the open field, lower ratio entries in open arms in the elevated plus maze and increased immobility time on the second day of the forced swim test
Title: Mood and memory-associated behaviors in neuropeptide Y5 knockout mice.
data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects.
Title: Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.
These studies demonstrate the pivotal, combined role of both Y1 and Y5 receptors in the mediation of food intake.
Title: Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice.
These results do not support a potential role for single transgene overexpression of Y5 receptors for modulating anxiety-/depression-like behaviours or seizures in adult mice.
Title: Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

PMC28100P2 (e-PCR)
- UniSTS:272403

PMC123072P1 (e-PCR)
- UniSTS:270434

NoName (e-PCR)
- UniSTS:491400

Npy5r (e-PCR), detects polymorphism
- UniSTS:531348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide Y receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pancreatic polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide YY receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in generation of ovulation cycle rhythm	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuropeptide Y receptor type 5

Names: NPY-Y5 receptor; Y5 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358957.1 → NP_001345886.1 neuropeptide Y receptor type 5

Status: VALIDATED

Source sequence(s)

AC100541

Consensus CDS

CCDS22335.1

UniProtKB/Swiss-Prot

O35380, O70342, Q9JMK1

UniProtKB/TrEMBL

Q543U8

Conserved Domains (1) summary

cd15398
Location:63 → 456

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001358958.1 → NP_001345887.1 neuropeptide Y receptor type 5

Status: VALIDATED

Source sequence(s)

AC100541

Consensus CDS

CCDS22335.1

UniProtKB/Swiss-Prot

O35380, O70342, Q9JMK1

UniProtKB/TrEMBL

Q543U8

Related

ENSMUSP00000148589.2, ENSMUST00000212563.2

Conserved Domains (1) summary

cd15398
Location:63 → 456

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_016708.3 → NP_057917.2 neuropeptide Y receptor type 5

See identical proteins and their annotated locations for NP_057917.2

Status: VALIDATED

Source sequence(s)

AK045587, BB346009, BB868845, BY008559, BY655564

Consensus CDS

CCDS22335.1

UniProtKB/Swiss-Prot

O35380, O70342, Q9JMK1

UniProtKB/TrEMBL

Q543U8

Related

ENSMUSP00000065157.8, ENSMUST00000070810.8

Conserved Domains (1) summary

cd15398
Location:63 → 456

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

67132617..67140746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153813.1 → XP_036009706.1 neuropeptide Y receptor type 5 isoform X1

UniProtKB/Swiss-Prot

O35380, O70342, Q9JMK1

UniProtKB/TrEMBL

Q543U8

Conserved Domains (1) summary

cd15398
Location:63 → 456

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors