Opn4 opsin 4 (melanopsin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Opn4provided by MGI
Official Full Name: opsin 4 (melanopsin)provided by MGI
Primary source: MGI:MGI:1353425
See related: Ensembl:ENSMUSG00000021799 AllianceGenome:MGI:1353425
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm533; 1110007J02Rik
Summary: Enables G protein-coupled photoreceptor activity. Involved in several processes, including hyaloid vascular plexus regression; optokinetic behavior; and phototransduction. Acts upstream of or within several processes, including detection of temperature stimulus involved in thermoception; entrainment of circadian clock by photoperiod; and thermotaxis. Located in sperm head plasma membrane. Is expressed in eye and future brain. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 1.8), thymus adult (RPKM 0.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.83 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (34312575..34322099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34590618..34600142, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes.
Title: Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes.
Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects.
Title: Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects.
Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes.
Title: Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes.
Contribution of M-opsin-based color vision to refractive development in mice.
Title: Contribution of M-opsin-based color vision to refractive development in mice.
Photic Regulation of Circadian Rhythms and Voluntary Ethanol Intake: Role of Melanopsin-expressing Intrinsically Photosensitive Retinal Ganglion Cells.
Title: Photic Regulation of Circadian Rhythms and Voluntary Ethanol Intake: Role of Melanopsin-expressing Intrinsically Photosensitive Retinal Ganglion Cells.
Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes.
Title: Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes.
Rhodopsin and melanopsin coexist in mammalian sperm cells and activate different signaling pathways for thermotaxis.
Title: Rhodopsin and melanopsin coexist in mammalian sperm cells and activate different signaling pathways for thermotaxis.
A bulk negative charge on melanopsin's (Opn4) C-terminus is centered at second cluster of putative C-terminal phosphorylation sites on the proximal region, but neighboring serine and threonine residues are necessary and capable of contributing to Opn4 deactivation as well. This suggests a unique level of flexibility in the capability of Opn4 C-terminus to regulate phototransduction deactivation through phosphorylation.
Title: Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation.
that very few brain targets receive convergent input from both opn4 intrinsically photosensitive retinal ganglion subpopulations, suggesting that each subpopulation drives a specific subset of light-driven behaviors
Title: Divergent projection patterns of M1 ipRGC subtypes.
beta-arrestins regulate different aspects of melanopsin photoresponses and allow intrinsically photosensitive retinal ganglion cells-sustained responses under prolonged illumination.
Title: Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

Opn4 (e-PCR), detects polymorphism
- UniSTS:527469

Opn4 (e-PCR), detects polymorphism
- UniSTS:265676

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-cis retinal binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled photoreceptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optokinetic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm head plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: melanopsin

Names: opsin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128599.1 → NP_001122071.1 melanopsin isoform 2

See identical proteins and their annotated locations for NP_001122071.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC114543

Consensus CDS

CCDS49446.1

UniProtKB/Swiss-Prot

Q9QXZ9

Related

ENSMUSP00000126136.2, ENSMUST00000168444.9

Conserved Domains (2) summary

pfam00001
Location:86 → 347

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 244

7tm_4; Olfactory receptor
NM_013887.2 → NP_038915.1 melanopsin isoform 1

See identical proteins and their annotated locations for NP_038915.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AC114543

Consensus CDS

CCDS26943.1

UniProtKB/Swiss-Prot

A4QPG3, B2C712, Q9QXZ9

Related

ENSMUSP00000022331.3, ENSMUST00000022331.3

Conserved Domains (2) summary

pfam00001
Location:86 → 347

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 244

7tm_4; Olfactory receptor