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    Dlec1 deleted in lung and esophageal cancer 1 [ Mus musculus (house mouse) ]

    Gene ID: 320256, updated on 12-May-2024

    Summary

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    Official Symbol
    Dlec1provided by MGI
    Official Full Name
    deleted in lung and esophageal cancer 1provided by MGI
    Primary source
    MGI:MGI:2443671
    See related
    Ensembl:ENSMUSG00000038060 AllianceGenome:MGI:2443671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630005C06Rik
    Summary
    Predicted to enable alpha-tubulin binding activity and beta-tubulin binding activity. Involved in spermatogenesis. Predicted to be located in cytosol. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 9.1), testis adult (RPKM 9.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dlec1 in Genome Data Viewer
    Location:
    9 F3; 9 71.32 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118927720..118977314)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119102444..119148246)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene villin-like Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E9778 Neighboring gene STARR-positive B cell enhancer ABC_E9779 Neighboring gene acetyl-Coenzyme A acyltransferase 1B Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 14 Neighboring gene STARR-seq mESC enhancer starr_25468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dlec1 is required for spermatogenesis and male fertility in mice. Okitsu Y, et al. Sci Rep, 2020 Nov 3. PMID 33144677, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dlec1 is required for spermatogenesis and male fertility in mice.
      Title: Dlec1 is required for spermatogenesis and male fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    deleted in lung and esophageal cancer protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368820.1 → NP_001355749.1  deleted in lung and esophageal cancer protein 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC055818

    2. NM_001368821.1 → NP_001355750.1  deleted in lung and esophageal cancer protein 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC055818

    3. NM_177117.5 → NP_796091.2  deleted in lung and esophageal cancer protein 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC055818
      Consensus CDS
      CCDS52963.1
      UniProtKB/TrEMBL
      E9Q8C0
      Related
      ENSMUSP00000128874.2, ENSMUST00000165231.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118927720..118977314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512152.5 → XP_006512215.1  deleted in lung and esophageal cancer protein 1 homolog isoform X1

    2. XM_006512155.5 → XP_006512218.1  deleted in lung and esophageal cancer protein 1 homolog isoform X4

    3. XM_006512154.5 → XP_006512217.1  deleted in lung and esophageal cancer protein 1 homolog isoform X3

      UniProtKB/TrEMBL
      D3Z6E8
      Related
      ENSMUSP00000122380.2, ENSMUST00000140326.8

    4. XM_006512156.5 → XP_006512219.1  deleted in lung and esophageal cancer protein 1 homolog isoform X5

    5. XM_006512153.5 → XP_006512216.1  deleted in lung and esophageal cancer protein 1 homolog isoform X2

    6. XM_036155059.1 → XP_036010952.1  deleted in lung and esophageal cancer protein 1 homolog isoform X6

      Conserved Domains (1) summary
      cl13764
      Location:605 → 710
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    7. XM_036155060.1 → XP_036010953.1  deleted in lung and esophageal cancer protein 1 homolog isoform X6

      Conserved Domains (1) summary
      cl13764
      Location:605 → 710
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    8. XM_006512158.5 → XP_006512221.1  deleted in lung and esophageal cancer protein 1 homolog isoform X7

    9. XM_006512159.1 → XP_006512222.1  deleted in lung and esophageal cancer protein 1 homolog isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLA1.1 GenPept UniProtKB/Swiss-Prot:Q8BLA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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