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    Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific [ Mus musculus (house mouse) ]

    Gene ID: 65967, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eefsecprovided by MGI
    Official Full Name
    eukaryotic elongation factor, selenocysteine-tRNA-specificprovided by MGI
    Primary source
    MGI:MGI:2137092
    See related
    Ensembl:ENSMUSG00000033216 AllianceGenome:MGI:2137092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sec; Selb; mSelB
    Summary
    Enables several functions, including GTP binding activity; GTPase activity; and RNA binding activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Part of ribonucleoprotein complex. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.2), ovary adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eefsec in Genome Data Viewer
    Location:
    6 D1; 6 39.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88234318..88423489, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88257334..88446552, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene stem and progenitor enriched required for hematopoietic differentiation Neighboring gene Gata2R5 erythroid cis-regulatory module Neighboring gene GATA binding protein 2 Neighboring gene Gata2R6 erythroid cis-regulatory module Neighboring gene DnaJ heat shock protein family (Hsp40) member B8 Neighboring gene predicted gene, 57776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88415220-88415403 Neighboring gene predicted gene, 44264 Neighboring gene STARR-seq mESC enhancer starr_16584 Neighboring gene RuvB-like AAA ATPase 1 Neighboring gene predicted gene, 46965 Neighboring gene SEC61 translocon subunit alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. Dubey A, et al. PLoS One, 2016. PMID 27802322, Free PMC Article
    2. The selenocysteine-specific elongation factor contains a novel and multi-functional domain. Gonzalez-Flores JN, et al. J Biol Chem, 2012 Nov 9. PMID 22992746, Free PMC Article
    3. Supramolecular complexes mediate selenocysteine incorporation in vivo. Small-Howard A, et al. Mol Cell Biol, 2006 Mar. PMID 16508009, Free PMC Article
    4. Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum. Zhang S, et al. Mutat Res, 2002 Mar 20. PMID 11890935
    5. Decoding apparatus for eukaryotic selenocysteine insertion. Tujebajeva RM, et al. EMBO Rep, 2000 Aug. PMID 11265756, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables selenocysteine insertion sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within selenocysteine incorporation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in selenocysteine incorporation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within translational elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selenocysteine-specific elongation factor
    Names
    MJ0495-like protein SelB
    elongation factor sec

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411439.1 → NP_001398368.1  selenocysteine-specific elongation factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927
      UniProtKB/TrEMBL
      A0A0N4SUV6
      Related
      ENSMUSP00000144839.2, ENSMUST00000205179.3

    2. NM_001411440.1 → NP_001398369.1  selenocysteine-specific elongation factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    3. NM_001411441.1 → NP_001398370.1  selenocysteine-specific elongation factor isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    4. NM_001411442.1 → NP_001398371.1  selenocysteine-specific elongation factor isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    5. NM_001411443.1 → NP_001398372.1  selenocysteine-specific elongation factor isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    6. NM_001411444.1 → NP_001398373.1  selenocysteine-specific elongation factor isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    7. NM_001411445.1 → NP_001398374.1  selenocysteine-specific elongation factor isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    8. NM_001411446.1 → NP_001398375.1  selenocysteine-specific elongation factor isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC153694

    9. NM_001411447.1 → NP_001398376.1  selenocysteine-specific elongation factor isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927
      Related
      ENSMUSP00000145480.2, ENSMUST00000203213.3

    10. NM_001411448.1 → NP_001398377.1  selenocysteine-specific elongation factor isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC153694
      Related
      ENSMUSP00000144824.2, ENSMUST00000204459.3

    11. NM_001411449.1 → NP_001398378.1  selenocysteine-specific elongation factor isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153694

    12. NM_001411450.1 → NP_001398379.1  selenocysteine-specific elongation factor isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC153694

    13. NM_001411451.1 → NP_001398380.1  selenocysteine-specific elongation factor isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC153694

    14. NM_023060.4 → NP_075547.1  selenocysteine-specific elongation factor isoform 1

      See identical proteins and their annotated locations for NP_075547.1

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927
      Consensus CDS
      CCDS20335.1
      UniProtKB/Swiss-Prot
      Q6GTZ5, Q9JHW4
      UniProtKB/TrEMBL
      Q3UGH6
      Related
      ENSMUSP00000131207.2, ENSMUST00000165242.4
      Conserved Domains (4) summary
      cd01889
      Location:8 → 197
      SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
      pfam00009
      Location:8 → 195
      GTP_EFTU; Elongation factor Tu GTP binding domain
      cd03696
      Location:210 → 292
      SelB_II; Domain II of elongation factor SelB
      cd04094
      Location:297 → 437
      eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

    RNA

    1. NR_149744.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    2. NR_177254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    3. NR_177255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    4. NR_177256.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    5. NR_177257.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    6. NR_177258.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    7. NR_177259.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    8. NR_177260.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    9. NR_177261.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    10. NR_177262.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    11. NR_177263.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    12. NR_177264.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    13. NR_177265.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694

    14. NR_177266.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153694, AC153927

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88234318..88423489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHW4.2 GenPept UniProtKB/Swiss-Prot:Q9JHW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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