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    Serpinb9d serine (or cysteine) peptidase inhibitor, clade B, member 9d [ Mus musculus (house mouse) ]

    Gene ID: 20726, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Serpinb9dprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 9dprovided by MGI
    Primary source
    MGI:MGI:894667
    See related
    Ensembl:ENSMUSG00000054266 AllianceGenome:MGI:894667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AT2; Spi9; ovalbumin
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of endopeptidase activity; protection from natural killer cell mediated cytotoxicity; and response to bacterium. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 22.5) See more
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    Genomic context

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    See Serpinb9d in Genome Data Viewer
    Location:
    13 A3.3; 13 13.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33376938..33387964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33192955..33203981)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34117 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9c Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9e Neighboring gene predicted gene, 40905

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575
    2. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
    3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) proteinase inhibitor, clade B, member 9d
    Names
    serine protease inhibitor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011460.3 → NP_035590.1  serine (or cysteine) proteinase inhibitor, clade B, member 9d

      See identical proteins and their annotated locations for NP_035590.1

      Status: VALIDATED

      Source sequence(s)
      AK028382, AL645704, D19505
      Consensus CDS
      CCDS26434.1
      UniProtKB/TrEMBL
      Q80Y29, Q8BMT0
      Related
      ENSMUSP00000067710.3, ENSMUST00000067198.3
      Conserved Domains (1) summary
      cl38926
      Location:1 → 377
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33376938..33387964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516630.3 → XP_006516693.1  serine (or cysteine) proteinase inhibitor, clade B, member 9d isoform X1

      See identical proteins and their annotated locations for XP_006516693.1

      UniProtKB/TrEMBL
      Q80Y29, Q8BMT0
      Conserved Domains (1) summary
      cl38926
      Location:1 → 377
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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