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    Trmt1l tRNA methyltransferase 1 like [ Mus musculus (house mouse) ]

    Gene ID: 98685, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Trmt1lprovided by MGI
    Official Full Name
    tRNA methyltransferase 1 likeprovided by MGI
    Primary source
    MGI:MGI:1916185
    See related
    Ensembl:ENSMUSG00000053286 AllianceGenome:MGI:1916185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trm1l; C1orf25; Trm1-like; 1190005F20Rik
    Summary
    Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Acts upstream of or within adult locomotory behavior. Predicted to be active in nucleus. Is expressed in several structures, including axial skeleton; brown fat; nervous system; olfactory epithelium; and respiratory system. Orthologous to human TRMT1L (tRNA methyltransferase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.6), CNS E14 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 G1; 1 64.12 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151304293..151333934)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151428542..151458183)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10138 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153191350-153191651 Neighboring gene STARR-positive B cell enhancer ABC_E3313 Neighboring gene influenza virus NS1A binding protein Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene microRNA 7682 Neighboring gene STARR-seq mESC enhancer starr_02619 Neighboring gene ring finger protein 2 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Vauti F, et al. Gene, 2007 Mar 15. PMID 17198746
    2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC70241

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TRMT1-like protein
    NP_001344498.1
    NP_001344499.1
    NP_081152.2
    XP_030099757.1
    XP_036010624.1
    XP_036010625.1
    XP_036010628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357569.1 → NP_001344498.1  TRMT1-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165946
      UniProtKB/Swiss-Prot
      A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68
      Conserved Domains (2) summary
      cl17173
      Location:225 → 666
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl22851
      Location:157 → 202
      PHD_SF; PHD finger superfamily

    2. NM_001357570.1 → NP_001344499.1  TRMT1-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AI853808, AK148524, BC064024
      Conserved Domains (1) summary
      cl17173
      Location:16 → 419
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_026876.4 → NP_081152.2  TRMT1-like protein isoform 1

      See identical proteins and their annotated locations for NP_081152.2

      Status: VALIDATED

      Source sequence(s)
      AI853808, AK148524, BC110425
      Consensus CDS
      CCDS15361.1
      UniProtKB/Swiss-Prot
      A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68
      UniProtKB/TrEMBL
      A0A0R4J0U8
      Related
      ENSMUSP00000068309.6, ENSMUST00000065625.12
      Conserved Domains (2) summary
      cl17173
      Location:225 → 687
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl22851
      Location:157 → 202
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      151304293..151333934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154732.1 → XP_036010625.1  TRMT1-like protein isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:225 → 425
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_036154731.1 → XP_036010624.1  TRMT1-like protein isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:72 → 534
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_030243897.2 → XP_030099757.1  TRMT1-like protein isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:16 → 419
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_036154735.1 → XP_036010628.1  TRMT1-like protein isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:16 → 398
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RSY6.1 GenPept UniProtKB/Swiss-Prot:A2RSY6

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