Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka4provided by MGI
Official Full Name: ribosomal protein S6 kinase, polypeptide 4provided by MGI
Primary source: MGI:MGI:1930076
See related: Ensembl:ENSMUSG00000118668 AllianceGenome:MGI:1930076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msk2; 90kDa; mMSK2; 1110069D02Rik
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Predicted to act upstream of or within inflammatory response and phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in 1st branchial arch maxillary component; heart; maxillary process; and sensory organ. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 18.4), adrenal adult (RPKM 18.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.08 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6806573..6819513, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6829084..6842145, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

regulator of nucleosomal remodelling in the diabetic milieu
Title: miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.
chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development
Title: The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.
Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2.
Title: Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis
Title: Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
MSK1/2 knockout results in reduced IL-10 secretion.
Title: MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.
data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone
Title: Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells.
Title: Characterization of the cellular action of the MSK inhibitor SB-747651A.
MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation.
Title: The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.
These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.
Title: Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.
MSK1/2 regulate pri-miR-212/132 transcription via the phosphorylation of CREB.
Title: Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rps6ka4 (e-PCR), detects polymorphism
- UniSTS:527523

AF074714 (e-PCR)
- UniSTS:181183

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-4

Names: 90 kDa ribosomal protein S6 kinase 4; RLSK; RSK-like protein kinase; S6K-alpha-4; mitogen- and stress-activated protein kinase-2; nuclear mitogen- and stress-activated protein kinase 2; ribosomal protein S6 kinase, 90kD, polypeptide 4

NP_064308.2

EC 2.7.11.1

XP_017173750.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019924.2 → NP_064308.2 ribosomal protein S6 kinase alpha-4

See identical proteins and their annotated locations for NP_064308.2

Status: VALIDATED

Source sequence(s)

AC120557, AK089467, BF465098, BP759267, CF616720, CJ065157

Consensus CDS

CCDS37899.1

UniProtKB/Swiss-Prot

Q3U3M8, Q91X18, Q9Z2B9

Related

ENSMUSP00000159422.2, ENSMUST00000239527.1

Conserved Domains (3) summary

smart00220
Location:33 → 301

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05614
Location:32 → 364

STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2

cd14180
Location:404 → 714

STKc_MSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6806573..6819513 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318261.3 → XP_017173750.1 ribosomal protein S6 kinase alpha-4 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 301

PKc_like; Protein Kinases, catalytic domain