Gorasp1 golgi reassembly stacking protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gorasp1provided by MGI
Official Full Name: golgi reassembly stacking protein 1provided by MGI
Primary source: MGI:MGI:1921748
See related: Ensembl:ENSMUSG00000032513 AllianceGenome:MGI:1921748
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P65; GOLPH5; GRASP65; 5430411C10Rik
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within Golgi organization and protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in cortical layer V and hippocampus CA1. Orthologous to human GORASP1 (golgi reassembly stacking protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 25.3), genital fat pad adult (RPKM 21.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 71.33 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (119754739..119766624, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119925673..119937558, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of GORASPs in Golgi apparatus organization in vivo.
Title: The function of GORASPs in Golgi apparatus organization in vivo.
GRASP65 phosphorylation may have a critical role in inducing cell death.
Title: The role of Golgi reassembly and stacking protein 65 phosphorylation in H(2)O(2)-induced cell death and Golgi morphological changes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW743035 (e-PCR)
- UniSTS:208466

D1S3693 (e-PCR)
- UniSTS:474271

MARC_16103-16104:1018028206:1 (e-PCR)
- UniSTS:267961

D9Mit216 (e-PCR), detects polymorphism
- UniSTS:131774

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi reassembly-stacking protein 1

Names: golgi peripheral membrane protein p65; golgi reassembly-stacking protein of 65 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028976.2 → NP_083252.1 Golgi reassembly-stacking protein 1

See identical proteins and their annotated locations for NP_083252.1

Status: PROVISIONAL

Source sequence(s)

AC124662

Consensus CDS

CCDS23619.1

UniProtKB/Swiss-Prot

Q91X51, Q9D3L9

UniProtKB/TrEMBL

Q3TCN5

Related

ENSMUSP00000035099.8, ENSMUST00000035099.9

Conserved Domains (2) summary

pfam04495
Location:68 → 204

GRASP55_65; GRASP55/65 PDZ-like domain

cl00117
Location:14 → 99

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...