Icosl icos ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Icoslprovided by MGI
Official Full Name: icos ligandprovided by MGI
Primary source: MGI:MGI:1354701
See related: Ensembl:ENSMUSG00000000732 AllianceGenome:MGI:1354701
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; mKIAA0653
Summary: Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 32.9), mammary gland adult (RPKM 16.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77904921..77915359)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (78069368..78079525)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
Title: A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Title: Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
Title: Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
Title: ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
work identified a potentially novel role for ICOSL, which serves as an endogenous alphavbeta3-selective antagonist to maintain glomerular filtration.
Title: Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist.
study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
Title: ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.
study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1-deficient mice occur independently of CD275(B7-H2)
Title: CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.
The expression of ICOSL in the cornea and the ICOS-mediated induction of Foxp3+ CD4+ regulatory T cells may contribute to successful corneal allograft survival.
Title: Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production
Title: Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236389

BG071784 (e-PCR), detects polymorphism
- UniSTS:259047

AU044799 (e-PCR)
- UniSTS:159997

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in isotype switching	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of activated T cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ICOS ligand

Names: B7 homolog 2; B7-like protein Gl50; B7-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015790.3 → NP_056605.1 ICOS ligand precursor

See identical proteins and their annotated locations for NP_056605.1

Status: PROVISIONAL

Source sequence(s)

AC153507

Consensus CDS

CCDS35956.1

UniProtKB/Swiss-Prot

Q9JHJ8

UniProtKB/TrEMBL

A0A1W2P6Q2, Q544C7

Related

ENSMUSP00000101032.2, ENSMUST00000105393.3

Conserved Domains (2) summary

smart00410
Location:52 → 140

IG_like; Immunoglobulin like

cl11960
Location:166 → 253

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

77904921..77915359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155889.1 → XP_036011782.1 ICOS ligand isoform X1

Conserved Domains (3) summary

cd00096
Location:256 → 263

Ig; Ig strand B [structural motif]

cd20935
Location:123 → 236

IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)

cl11960
Location:241 → 328

Ig; Immunoglobulin domain