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    Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 19714, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rev3lprovided by MGI
    Official Full Name
    REV3 like, DNA directed polymerase zeta catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1337131
    See related
    Ensembl:ENSMUSG00000019841 AllianceGenome:MGI:1337131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rev; Rev3; Sez4
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Acts upstream of or within DNA repair. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and nose. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 11.7), whole brain E14.5 (RPKM 9.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B1; 10 21.04 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39607557..39751207)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39731561..39875211)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621 Neighboring gene STARR-seq mESC enhancer starr_26404 Neighboring gene STARR-seq mESC enhancer starr_26405 Neighboring gene STARR-seq mESC enhancer starr_26406 Neighboring gene predicted gene, 22105 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene major facilitator superfamily domain containing 4B4 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung. Ishii Y, et al. Mutagenesis, 2021 May 31. PMID 33544859
    2. A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication. Takezawa J, et al. DNA Repair (Amst), 2021 Feb. PMID 33387704
    3. Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cells. Yoon JH, et al. Genes Dev, 2010 Jan 15. PMID 20080950, Free PMC Article
    4. Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions. Jansen JG, et al. DNA Repair (Amst), 2009 Dec 3. PMID 19783229
    5. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. Schenten D, et al. J Exp Med, 2009 Feb 16. PMID 19204108, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of DNA polymerase zeta engages an innate immune response.
      Title: Disruption of DNA polymerase ζ engages an innate immune response.
    2. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
      Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    3. The role of DNA polymerase zeta in benzo[a]pyrene-induced mutagenesis in the mouse lung.
      Title: The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.
    4. DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
      Title: DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
    5. A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
      Title: A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
    6. The roles of POLZ in DNA replication and repair have been summarized. (Review)
      Title: DNA polymerase ζ in DNA replication and repair.
    7. Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L
      Title: DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
    8. A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
      Title: A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
    9. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta
      Title: The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.
    10. results can be unified by a model in which slowly dividing cells accumulate replication-associated DNA breaks but otherwise survive Rev3L deletion, but functional polzeta is essential for responses requiring rapid proliferation
      Title: Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (14)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase zeta catalytic subunit
    Names
    REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like
    seizure-related protein 4
    NP_035394.2
    XP_006512685.1
    XP_006512686.1
    XP_006512687.1
    XP_036011601.1
    XP_036011602.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011264.3 → NP_035394.2  DNA polymerase zeta catalytic subunit

      See identical proteins and their annotated locations for NP_035394.2

      Status: VALIDATED

      Source sequence(s)
      AB031049, AC118733, AC119943
      Consensus CDS
      CCDS23790.1
      UniProtKB/Swiss-Prot
      E9Q1X0, Q61493, Q9JMD6, Q9QWX6
      Related
      ENSMUSP00000019986.7, ENSMUST00000019986.13
      Conserved Domains (5) summary
      cd05778
      Location:2286 → 2524
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2550 → 2998
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:2550 → 2997
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:3034 → 3101
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:746 → 1132
      DUF4683; Domain of unknown function (DUF4683)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39607557..39751207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512622.3 → XP_006512685.1  DNA polymerase zeta catalytic subunit isoform X1

      Conserved Domains (5) summary
      cd05778
      Location:2287 → 2525
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2551 → 2999
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:6 → 195
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:3035 → 3102
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:747 → 1133
      DUF4683; Domain of unknown function (DUF4683)

    2. XM_006512623.5 → XP_006512686.1  DNA polymerase zeta catalytic subunit isoform X2

      Conserved Domains (5) summary
      cd05778
      Location:2209 → 2447
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2473 → 2921
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:4 → 117
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:2957 → 3024
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:669 → 1055
      DUF4683; Domain of unknown function (DUF4683)

    3. XM_036155709.1 → XP_036011602.1  DNA polymerase zeta catalytic subunit isoform X4

      Conserved Domains (5) summary
      cd05778
      Location:1941 → 2179
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2205 → 2653
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam14260
      Location:2689 → 2756
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:407 → 787
      DUF4683; Domain of unknown function (DUF4683)
      cd22287
      Location:1525 → 1547
      REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins

    4. XM_036155708.1 → XP_036011601.1  DNA polymerase zeta catalytic subunit isoform X4

      Conserved Domains (5) summary
      cd05778
      Location:1941 → 2179
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2205 → 2653
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam14260
      Location:2689 → 2756
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:407 → 787
      DUF4683; Domain of unknown function (DUF4683)
      cd22287
      Location:1525 → 1547
      REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins

    5. XM_006512624.5 → XP_006512687.1  DNA polymerase zeta catalytic subunit isoform X3

      Conserved Domains (5) summary
      cd05778
      Location:2208 → 2446
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2472 → 2920
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:4 → 117
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:2956 → 3023
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:668 → 1054
      DUF4683; Domain of unknown function (DUF4683)

    RNA

    1. XR_004936129.1 RNA Sequence

      Related
      ENSMUST00000131186.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61493.3 GenPept UniProtKB/Swiss-Prot:Q61493

    Gene LinkOut

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